Research Topic

Inflammatory Responses to Applied Biomaterials in Orthopedic Surgery

About this Research Topic

A key for the long-term survival and function of surgically implanted biomaterials is that they do not elicit a detrimental immune response. Biomaterials can have profound impacts on the host innate and adaptive immune system. The recent cases of clinical complications caused by metal-on-metal hip arthroplasty have demonstrated the potentially catastrophic consequences of problematic biomaterials in patients. Advanced implant design aims to make use of host immune response to improve implant integration, while also avoiding its perpetuation, which can lead to chronic inflammation and foreign body reactions that cause loss of the intended function. A comprehensive communication between material scientists, immunologists and surgeons will help to gain better understanding of host inflammatory responses to surgically implanted biomaterials. Thus it will benefit the design of new biomaterials by material scientists and better clinical success of surgical implants.

The aim of this Research Topic is to provide a platform for comprehensive communication between biomaterial scientists and surgeons who perform the biomaterial implantations.

The scope of the Research Topic is to cover the following areas:

(1) Innate/adaptive immune response to biomaterials;
(2) Inflammation of host tissue following biomaterial implantation;
(3) Clinical outcomes/trials of biomaterials;
(4) Case reports on (1) through (3).

Specific topics will include, but are not limited to the following:

(1) Reviews or minireviews on inflammatory/immune responses to applied biomaterials in surgery;
(2) Basic/clinical research in this area; and
(3) Clinical case reports that represent inflammation/immune response of host tissue against implanted biomaterials in surgery.


Keywords: Inflammation, Immunology, Biomaterials, Surgery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

A key for the long-term survival and function of surgically implanted biomaterials is that they do not elicit a detrimental immune response. Biomaterials can have profound impacts on the host innate and adaptive immune system. The recent cases of clinical complications caused by metal-on-metal hip arthroplasty have demonstrated the potentially catastrophic consequences of problematic biomaterials in patients. Advanced implant design aims to make use of host immune response to improve implant integration, while also avoiding its perpetuation, which can lead to chronic inflammation and foreign body reactions that cause loss of the intended function. A comprehensive communication between material scientists, immunologists and surgeons will help to gain better understanding of host inflammatory responses to surgically implanted biomaterials. Thus it will benefit the design of new biomaterials by material scientists and better clinical success of surgical implants.

The aim of this Research Topic is to provide a platform for comprehensive communication between biomaterial scientists and surgeons who perform the biomaterial implantations.

The scope of the Research Topic is to cover the following areas:

(1) Innate/adaptive immune response to biomaterials;
(2) Inflammation of host tissue following biomaterial implantation;
(3) Clinical outcomes/trials of biomaterials;
(4) Case reports on (1) through (3).

Specific topics will include, but are not limited to the following:

(1) Reviews or minireviews on inflammatory/immune responses to applied biomaterials in surgery;
(2) Basic/clinical research in this area; and
(3) Clinical case reports that represent inflammation/immune response of host tissue against implanted biomaterials in surgery.


Keywords: Inflammation, Immunology, Biomaterials, Surgery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 November 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 November 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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