Cerebrovascular diseases manifest as disruptive and deteriorating conditions, gravely impacting cognitive functions by altering the neurophysiological structure of the brain. With particular attention to diseases like Moyamoya and vascular malformations, the occlusion of internal carotid arteries, and abnormal vascular networks, these diseases lead to progressive cognitive and functional impairments. Although recent researches have offered valuable insights into the pathophysiology, much remains hazy, including the mechanisms through which these diseases alter cognitive processes and brain structure.

This Research Topic is meticulously designed to harness a more profound understanding of braın structural changes and cognitive dysfunctions caused by cerebrovascular diseases like Moyamoya disease and vascular malformations. It intends to invite research detailing individual cognitive profiles, unveiling neuropathological mechanisms and discussing potential therapeutic interventions.

The overarching aim is to enrich the existing knowledge pool, enabling advances in early diagnosis, intervention strategies, and management of cognitive impairment following these cerebrovascular diseases. We underscore the wide-reaching spectrum of this topic, inviting both empirical and theoretical research. Authors can consider focusing on themes that:

• Investigate the neuropathological mechanisms underlying the cognitive deficits in Moyamoya disease and vascular malformations.

• Decode the brain structural alterations and their patterns arising due to these diseases using neuroimaging techniques and how it correlates with specific cognitive deficits.

• Explicate individual patterns of cognitive impairment in people with Moyamoya disease and vascular malformations.

• Develop predictive models that can identify patients at a higher risk for cognitive decline following the disease onset.

• Discuss potential therapeutic approaches and interventions to alleviate cognitive impairment in patients with these cerebrovascular ailments.

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Alterations in brain structure and cognitive function caused by cerebrovascular diseases Volume III