Translational immunology: from immune monitoring to precision medicine

Translational immunology has entered a new era in which high-dimensional immune profiling, advanced in vitro modeling systems, and artificial intelligence-driven analytics converge to bridge the gap between mechanistic insights and clinical application. Despite major advances, a key challenge remains: transforming complex immune signatures into clinically actionable biomarkers.

This Research Topic aims to bring together multidisciplinary approaches that enable the transition from immune monitoring to precision medicine. We particularly welcome studies integrating flow cytometry–based immunophenotyping, cytokine profiling, exosome-mediated immune communication, and single-cell technologies with computational modeling and machine learning.

A special focus will be placed on emerging model systems such as iPSC-derived organoids and microglia organoid co-culture platforms, which provide new opportunities to study immune–tissue interactions in neurodegenerative and inflammatory diseases. In addition, studies addressing immunosenescence, chronic inflammation, and immune exhaustion, particularly in relation to clinical outcomes, are highly encouraged.

We also invite contributions in cancer immunology, autoimmunity, transplantation, and infectious diseases, especially those identifying novel immune signatures, biomarkers, or therapeutic targets. The integration of multi-omics data with explainable AI approaches represents a key priority for developing interpretable and clinically applicable decision-support systems.

Overall, this Research Topic aims to establish a framework in which immune profiling becomes predictive, integrative, and clinically actionable.

Experts in neuroimmunology, immunosenescence, systems immunology, cancer immunology, and AI-driven immune profiling have been identified, and the list will be further expanded during the invitation phase.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Translational Immunology: Immune Profiling: Single-Cell Multi-omics: Artificial Intelligence in Immunology: Precision Medicine

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.