About this Research Topic
In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family – IL-1α and IL-1β. These potent pro-inflammatory cytokines have been the subject of much research in the areas of fever, inflammation as well as their role in a myriad of inflammatory-associated diseases. Many related cytokines, with both pro- and anti-inflammatory properties, including IL-18, IL-33, IL-36, IL-37, IL-38, IL-1 receptor antagonist (IL-1Ra), and IL-36Ra, have since been identified. In addition to the 11 identified cytokine members of this family, there are now multiple discrete receptor family members, comprising functional receptors that are able to activate downstream signalling cascades, as well as several decoy and inhibitory receptors.
Whilst IL-1 has been identified for several decades, new information concerning its role in disease is constantly emerging. In addition, many members of this family have now been identified as being critical for the development of diverse inflammatory and allergic diseases. In this Research Topic, we aim to gather a series of articles that discuss IL-1 biology; the signaling pathways activated by IL-1 family members and negative regulation of these pathways. Given the recent explosion of this field in terms of the more novel members of this family e.g. IL-33 and IL-37, we also aim to cover studies that discuss newer family members and their role in specific diseases.
In this Research Topic, we welcome the submission of Reviews, Mini-Reviews, Original Research and Perspective articles that cover the following sub-topics:
1. Review of IL-1 family members, signalling pathways and their regulation, processing and secretion.
2. Review of inflammasome activated caspase-dependent cleavage of IL-1 family members.
3. Caspase-independent cleavage of IL-1 family members.
4. IL-1alpha and IL-1beta as the gatekeepers of inflammation.
5. IL-1 family members and the key link between innate and adaptive immune responses.
6. IL-1 family members as regulators of tissue homeostasis.
7. IL-1 family members in cancer with a focus on IL-33.
8. IL-1 family members and Age Related Macular Degeneration (AMD); focus on IL-18.
9. IL-1 family members in Inflammatory Bowel Disease (IBD) with a focus on IL-18 and IL-33.
10. IL-1 family cytokines in liver diseases with a focus on IL-1 and IL-33.
11. IL-1 family members and their role in metabolic diseases including obesity and CVD.
12. IL-1 family members and airway diseases.
13. IL-1 family members and systemic autoimmune diseases e.g. rheumatoid arthritis.
14. IL-1 family and inherited autoinflammatory disease.
15. Regulatory members of the IL-1 family, e.g SIGIRR, and their role in regulating inflammation and disease.
16. Interactions between IL-1 family members and the microbiota.
17. IL-1 family members as pharmacological targets.
18. IL-1 family members in retinal degeneration with focus on IL-1 and IL-33.
19. IL-1 family members as regulators of angiogenesis.
20. IL-1 family members and psoriasis with a focus on IL-36.
21. IL-1 family members and atopic dermatitis with a focus on IL-18 and IL-33.
22. IL-1 family members in the CNS.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.