Research Topic

Nature and Nurture, Two Sides of The Coins - Where We Are In the Neuropsychiatric Disorder Research

  • Submission closed.

About this Research Topic

The last several decades have witnessed rapid advances in the research field of neuropsychiatric disorders such as schizophrenia, autism, and depression. Despite massive investment and considerable investigation, the precise aetiology of these diseases still remains incredibly variable and arguably ...

The last several decades have witnessed rapid advances in the research field of neuropsychiatric disorders such as schizophrenia, autism, and depression. Despite massive investment and considerable investigation, the precise aetiology of these diseases still remains incredibly variable and arguably controversial. Both genetic and non-genetic risk factors, as well as interactions and correlations between them, predispose toward neuropsychiatric and behavioral phenotypes. The involvement of liability genes has long been proposed by genetic epidemiology. However, molecular genetic studies have yielded limited success so far, and only a few susceptibility genes are definitely validated by functional analyses and animal studies. This ambiguous genetic picture is being rapidly reshaped through studies of whole genome interrogation, rare monogenic deletions, copy number variations, multiple sets of low risk common-DNA variants and epigenetic modifications. These genetic alterations can be either inherited or occur de novo, hence outlining a highly polygenic and heterogeneous nature. To date, either the liability genes/variants or the underlying mechanisms which lead to psychosis are far from clear and therefore, the prospects for improving clinical treatment are bleak. As a result, the current standard of care, involving either typical or atypical antipsychotic medication, is mostly palliative, has little effects on the long term prognosis, and frequently produces metabolic syndrome, featuring a spectrum of serious metabolic abnormalities including, but not limited to, obesity, diabetes and cardiovascular problems. This has in turn added additional layers of complexity.

In this Research Topic, we welcome submissions which describe the most recent findings and progress emerging from neuropsychiatric disorder research. We aim to address at least part of the aforementioned questions and to provide more detailed mechanistic insights for better understanding and early intervention of these refractory diseases.


Keywords: Neuropsychiatric Disorders, Neurodevelopment, Liability Genes, Metabolic Syndrome, Environmental interaction


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);