About this Research Topic
Over the past decade, there has been a greater understanding of genomic complexity in eukaryotes steered by the immense technological advances in sequencing of DNA and its corresponding RNA transcripts. It has become clear that human genome transcribes thousands of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs) and many long non-coding RNA (lncRNA) transcripts. These are exciting times for discovery of the biological scope and mechanisms of action for ncRNA molecules, which consequently have a great impact in development and diseases. The mechanisms of ncRNA regulation are starting to emerge from pioneering works, including their roles in epigenetics, enhancer function and post-transcriptional regulation, and recent approaches have provided evidence of essential involvement of ncRNAs in regulating the complex networks of signalling pathways. Moreover, unravelling how ncRNAs influence the regulation of cellular pathways is one of the research areas expected to impact most of the understanding of gene regulation in the next years.
ncRNAs have proven their ubiquity in cardiovascular biology from development to disease, from translational medicine to drug discovery. ncRNAs have been associated with cardiovascular systems since their evolution and are closely associated with cardiovascular development, biogenesis and repair. In the emerging field of RNA therapies for cardiovascular diseases, ncRNAs display potential as diagnostic biomarkers. In the role of signalling molecules, regulating the transcription of genes, ncRNAs may also prove fruitful as pharmacological agents, providing targeted therapy. The association of ncRNA with the cardiovascular system is proving to be a rather rich field for investigation. Further, technologies combined with bioinformatics and increasingly sophisticated molecular biology techniques, have created a competitive, rapidly changing research landscape associated with non-coding RNAs.
With that in mind, in this Research Topic, we welcome various articles (e.g. reviews, original research or methodology articles) in the research fields that offer great impact and therapeutic potential. Areas of interest include the development of novel non-coding RNA therapeutics towards cardiovascular disease, the potential of ncRNAs as biomarkers, the role of ncRNAs in cardiovascular development, and future research technologies and methods.
Keywords: Non-coding RNA, MicroRNAs, Functional genomics, Cardiovascular regeneration, RNA therapeutics
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