About this Research Topic
All living organisms constantly experience mechanical forces from their environment and translate these physical cues into biochemical signals at the cellular level. Using their mechanosensitive sensors, single cells can sense changes in their microenvironment such as stiffness of ECM substrate, shear forces, hydrostatic and osmotic pressures. Typically, these physical signals influence cellular behavior such as migration, survival, differentiation and proliferation and impact genome organization. If, however, these biomechanical forces become abnormal or incorrectly transduced in the cells, diseases can develop. Given the emerging importance of mechanical signal and sensing in cell function and human health, mechanobiology has rapidly grown as an interdisciplinary field that requires a concerted effort of multiple disciplines ranging from cell and developmental biology, to bioengineering , biophysics and micro-/nanotechnology to shed light on the complex interplay of forces and biological development.
In this Research Topic, we are soliciting original research as well as review papers covering effects of various types of forces (e.g., shear forces, osmotic pressures, hydrostatic pressures and ECM stiffness) on cells, as well as the effects of cell-generated forces on the environment and their impact on disease models. Manuscripts that focus on the fundamental understanding of the mechanotransduction and relevant to understanding of disease are especially welcome. Due to the interdisciplinary character of the research area, contributions from a wide range of fields starting from physical sciences, experimental and computational biology, engineering are sought after.
Keywords: Mechanobiology, Mechanotransduction, Tissue mechanics, Cell mechanics, Microenvironment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.