About this Research Topic
The influence of diet upon health is indisputable. This statement is based on a plethora of observational and interventional studies indicating that diet has a dramatic effect on the risk of developing non-communicable diseases. Dietary habits might have a direct influence on the risk and, thus, on the prevention, of most of the diseases that contribute to the major causes of premature death in industrialized countries: cardiovascular diseases, type II diabetes, neurodegenerative disorders, and some cancers. This incidence is postulated to reflect risk factors associated also to socioeconomic status, including an increased consumption of salt, sugar, and saturated fat, a reduced consumption of fruits, vegetables, and dietary fibre, poor dietary habits, smoking, obesity, and physical inactivity. For these reasons, nutritional sciences are becoming more and more relevant in the prevention of non-communicable diseases. However, taking into account the vast numbers of factors playing a role in this topic, comprehensive and multidisciplinary approaches are highly required. From a methodological point of view, the integration of metabolomics into this research field has led to a new scenario and the achievement of key insights. This article collection will provide clear examples of nutritional metabolomics that will reflect the state-of-the-art (and will set the frontiers of the future research), presenting guidance for future nutritional metabolomic studies while evaluating sample preparation, method development and biological interpretation. Nutritional interventions, consumer stratification, and population phenotyping approaches considering exogenous and/or endogenous metabolites that may serve as biomarkers of intake and biomarkers of effect are welcomed.
Keywords: Foodomics, Gut microbiota, Phytochemicals, Untargeted metabolomics, Biomarkers
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