Frontiers | Innovative Biomaterials and Regenerative Strategies for Dental Tissue Repair: From Biological Mechanisms to Clinical Translation

About this Research Topic

Submission deadlines

Manuscript Submission Deadline 3 January 2027
This Research Topic is currently accepting articles
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Background

Regenerative dentistry has rapidly evolved from traditional repair approaches toward biologically driven strategies that aim to restore the structure and function of dental and maxillofacial tissues. Advances in biomaterials science, molecular biology, and tissue engineering have provided new opportunities to enhance tissue regeneration, yet significant challenges remain in translating these innovations into predictable clinical outcomes.

This Research Topic aims to bring together cutting-edge studies and comprehensive reviews focusing on innovative regenerative strategies for dental restoration, with particular emphasis on the integration of biological mechanisms and translational applications. We welcome contributions that explore how emerging biomaterials, cell-based therapies, and molecular signaling pathways can be leveraged to improve tissue repair and regeneration in oral and maxillofacial contexts.

Key areas of interest include, but are not limited to:

Advanced biomaterials and nanoengineered systems for dental, periodontal, and bone regeneration

Cell-based therapies, including stem cells, exosomes, and bioactive factor delivery

Molecular mechanisms underlying tissue repair, such as osteogenesis, angiogenesis, inflammation, and immune modulation

Biomaterial–cell interactions and microenvironmental regulation in tissue regeneration

Strategies to enhance vascularization and integration of engineered tissues

Translational research bridging experimental findings with clinical applications

Clinical studies evaluating regenerative approaches in dentistry and oral surgery

Particular attention will be given to studies that combine mechanistic insights with therapeutic innovation, as well as interdisciplinary approaches that integrate biomaterials, nanotechnology, and molecular medicine. By fostering collaboration between basic scientists, biomaterial engineers, and clinicians, this Research Topic seeks to provide a comprehensive platform for advancing the field of regenerative dentistry and accelerating the translation of emerging technologies into clinical practice.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

Brief Research Report
Case Report
Classification
Clinical Trial
Community Case Study
Curriculum, Instruction, and Pedagogy
Data Report
Editorial
FAIR² Data

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Regenerative dentistry, Biomaterials, Tissue engineering, Stem cell therapy, Bone regeneration, Angiogenesis, Nanomedicine, Translational research

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.