Enhancing Sensitivity of Zebrafish Embryo Assays in Developmental Toxicity Screening

The zebrafish embryo assay is an established model in developmental toxicity screening, offering a balance of biological complexity and experimental efficiency. However, questions remain about its sensitivity in detecting substances with subtle or low-dose effects, particularly when compared to traditional mammalian models.

This Research Topic brings together work focused on improving the reliability and sensitivity of zebrafish embryo assays, including advances in endpoint selection, exposure protocols, imaging and data analysis, and the integration of omics approaches.

We welcome original research, reviews, and methods articles that address current limitations and explore how refined zebrafish-based models can better inform regulatory decision-making in developmental and reproductive toxicology.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Zebrafish embryo assay, Developmental toxicity, Danio rerio, New Approach Methodologies (NAMs), Reproductive toxicology

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.