MS
moisés silva
Department of Immuno-Physiology and Pharmacology, Abel Salazar Institute of Biomedical Sciences, University of Porto
Porto, Portugal
About this Research Topic
Submission deadlines
Manuscript Submission Deadline 22 December 2026
This Research Topic is currently accepting articles
Background
Autoimmune and chronic degenerative diseases represent an expanding global health challenge, affecting individuals across all age groups and significantly impacting quality of life. While pharmacological treatments remain the mainstay of care, emerging evidence highlights the essential role of lifestyle factors, particularly physical activity, in modulating immune function, inflammation, and disease outcomes.
This Research Topic, “Lifestyle and Physical Activity Interventions in Chronic Degenerative and Autoimmune Disease Prevention and Management,” aims to compile multidisciplinary perspectives exploring how exercise and lifestyle modifications can contribute to the prevention, progression control, and symptom management of autoimmune and chronic degenerative disorders.
We welcome contributions from basic, clinical, and applied sciences, including original research, reviews, and meta-analyses that address topics such as:
• The physiological and molecular mechanisms linking physical activity to immune regulation, neurodegeneration, and inflammation
• Clinical and behavioral outcomes of structured exercise programs in autoimmune and chronic degenerative populations
• Lifestyle and dietary interventions supporting immune balance, metabolic health, and disease-modifying outcomes
• Adherence, patient engagement, and the use of digital or community-based strategies in long-term management
• Integrative approaches combining lifestyle modification with pharmacological or rehabilitative therapies
By bridging immunology, physiology, neuroscience, public health, and behavioral science, this Research Topic seeks to advance evidence-based understanding of how lifestyle and physical activity interventions can inform preventive and therapeutic strategies for autoimmune and chronic degenerative diseases.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
- Brief Research Report
- Case Report
- Clinical Trial
- Conceptual Analysis
- Data Report
- Editorial
- FAIR² Data
- General Commentary
- Hypothesis and Theory
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
- Brief Research Report
- Case Report
- Clinical Trial
- Conceptual Analysis
- Data Report
- Editorial
- FAIR² Data
- General Commentary
- Hypothesis and Theory
- Methods
- Mini Review
- Opinion
- Original Research
- Perspective
- Policy and Practice Reviews
- Policy Brief
- Registered Report
- Review
- Study Protocol
- Systematic Review
- Technology and Code
Keywords: Autoimmune diseases, Chronic degenerative diseases, Physical activity, Exercise intervention, Immune regulation, Lifestyle modification, Inflammation, Neurodegeneration
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
