Insights in Aging, Metabolism and Redox Biology: 2026/2027

This Research Topic follows on from previous collections in this series.

The field of aging, metabolism, and redox biology has witnessed remarkable advancements, particularly in the last few years, as scientists have made significant strides in understanding the complex mechanisms underlying aging processes. Despite these achievements, the field continues to grapple with several pressing questions, such as the precise molecular pathways that govern aging and how metabolic and redox changes influence these processes. Recent studies have provided insights into the role of oxidative stress and metabolic alterations in aging, highlighting potential therapeutic targets for age-related diseases. However, there remains a gap in translating these findings into effective interventions that can mitigate the effects of aging. Ongoing debates focus on the balance between oxidative damage and redox signaling, and the need for a more comprehensive understanding of how these factors interact with metabolic pathways. This underscores the necessity for continued investigation to unravel the intricate network of interactions that contribute to aging and to develop strategies that can enhance healthspan and lifespan.

This research topic aims to illuminate the progress made over the past decade in the field of aging, metabolism, and redox biology, while also addressing the future challenges that lie ahead. By providing a comprehensive overview of recent developments and major accomplishments, this special edition seeks to inspire and guide researchers in identifying and overcoming the greatest challenges within the sub-disciplines. The goal is to foster a deeper understanding of the field and to chart a course for future research endeavors.

To gather further insights in the dynamic and evolving landscape of aging, metabolism, and redox biology, we welcome articles addressing, but not limited to, the following themes:

- The role of oxidative stress and redox signaling in aging.
- Metabolic pathways and their influence on aging processes.
- Novel therapeutic targets for age-related diseases.
- Interactions between metabolic and redox changes in aging.
- Strategies to enhance healthspan and lifespan.
- Recent technological advancements in aging research.
- Future perspectives and challenges in the field.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Oxidative stress, redox signaling, metabolic aging, mitochondrial dysfunction, therapeutic targets

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.