Community Series in Immune-Cardiac Axis: exploring immune response interactions with cardiovascular function in health and disease, volume II

This Research Topic is the second volume of the “Immune-Cardiac Axis: exploring immune response interactions with cardiovascular function in health and disease.” Community Series. Please see Volume I here.

The interplay between the immune system and the cardiovascular system, specifically the relationship between inflammatory molecules and the determinants of cardiovascular function, is vital to the maintenance of fitness and health, including during rest and strenuous physical activity. Innate and adaptive immune responses contribute to the onset and progression of acute coronary events, cardiac arrhythmias, inflammatory cardiac conditions, and heart failure. Immune responses play critical roles in specific clinical settings such as allo-immunity after heart transplantation, as well as inflammatory patterns in multi-organ dysfunction, depression and other mood states, and cardiovascular implications of post-acute sequelae of COVID. Building on the first volume of this Research Topic, the interplay and relationship between inflammatory molecules and the key determinants of cardiovascular function, preload, afterload, contractility and rhythm, continue to warrant systematic review as new evidence emerges.

Research on the interplay between the immune system and cardiovascular function, health and disease employ a variety of methodologies, ranging from basic science techniques to study 1) mechanisms, 2) cutting-edge translational relationships, and 3) clinical approaches in humans. In this second volume, we again bring together world-renowned research teams to provide further systematic insights into these relationships.

To gather further insights within the context of immune-cardiovascular interactions in physiological and pathological scenarios, we welcome Original Research, Systematic Review, Review, Mini-Review, Hypothesis & Theory, and Clinical Trial articles focusing on, but not limited to, the following sub-topics:

• Immune system interactions with determinants of cardiovascular function (preload, afterload, contractility, and rhythm) in health and during physical activity

• Immune system interactions with determinants of cardiovascular function (preload, afterload, contractility, and rhythm) in cardiac dysfunction

• Clinical implications of inflammatory mechanisms driving the onset and progression of cardiac diseases, including acute coronary syndromes, arrhythmias, myocarditis, cardiomyopathy, and heart failure

• Clinical implications of immune-mediated cardiovascular disorders post-heart transplantation

• Role of systemic inflammation linked to mood disorders in cardiovascular and multi-organ dysfunction syndromes

• Cardiovascular consequences of immune and inflammatory pathways in post-acute COVID-19 syndromes

• Role of immune systems in frailty and cardiovascular outcomes

• Immunomodulation and cardiovascular disease

Topic Editor Mario Deng has declared that he is a consultant for CareDx