Research Topic

Health-Related Complications of Acromegaly

About this Research Topic

Acromegaly is a chronic disease caused by growth hormone (GH) secreting pituitary adenoma. GH and its peripheral mediator insulin-like growth factor-1 (IGF-1) influence tissues overgrowth and metabolic complications. Most successful therapy of acromegaly is neurosurgical removal of the tumor. This is possible in less than half of the patient. Other patients require medical therapy (somatostatin receptor ligands, GH receptor antagonist, dopamine agonist or their combination) and/or stereotactic radiosurgery. Uncontrolled disease causes 1.5-2.5 fold increase in standardized mortality rate and about 10 yrs decrease of survival time. Main causes of premature mortality in acromegaly are cardiovascular, respiratory and neoplastic diseases.

Among cardiovascular diseases arterial hypertension, cardiomyopathy, hypertrophy, cardiac defects and arrhythmia have greatest impact. They can be influenced by diabetes mellitus, lipid disturbances and endothelial lesions, also. On the other hand, musculoskeletal disorders, spinal fractures and appearance changes are the causes of worsened quality of life. Moreover, some novel therapies can influence carbohydrate metabolism, and deteriorate patients status.

With this Research Topic the Topic Editors aim to gather all above mentioned aspects to ultimately foster the knowledge on acromegaly and its complications. Potential authors are welcomed to submit either original research articles or reviews.


Keywords: Acromegaly, Diabetes Mellitus, Cardiovascular Disease, Insulin Resistance, Atherosclerosis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Acromegaly is a chronic disease caused by growth hormone (GH) secreting pituitary adenoma. GH and its peripheral mediator insulin-like growth factor-1 (IGF-1) influence tissues overgrowth and metabolic complications. Most successful therapy of acromegaly is neurosurgical removal of the tumor. This is possible in less than half of the patient. Other patients require medical therapy (somatostatin receptor ligands, GH receptor antagonist, dopamine agonist or their combination) and/or stereotactic radiosurgery. Uncontrolled disease causes 1.5-2.5 fold increase in standardized mortality rate and about 10 yrs decrease of survival time. Main causes of premature mortality in acromegaly are cardiovascular, respiratory and neoplastic diseases.

Among cardiovascular diseases arterial hypertension, cardiomyopathy, hypertrophy, cardiac defects and arrhythmia have greatest impact. They can be influenced by diabetes mellitus, lipid disturbances and endothelial lesions, also. On the other hand, musculoskeletal disorders, spinal fractures and appearance changes are the causes of worsened quality of life. Moreover, some novel therapies can influence carbohydrate metabolism, and deteriorate patients status.

With this Research Topic the Topic Editors aim to gather all above mentioned aspects to ultimately foster the knowledge on acromegaly and its complications. Potential authors are welcomed to submit either original research articles or reviews.


Keywords: Acromegaly, Diabetes Mellitus, Cardiovascular Disease, Insulin Resistance, Atherosclerosis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

05 December 2018 Manuscript
07 January 2019 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

05 December 2018 Manuscript
07 January 2019 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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