About this Research Topic
The axon represents the main output structure of neurons. It carries neuronal information under the form of action potentials from the site of initiation at the axon initial segment (AIS) to the terminal located in some cases at several centimeters without attenuation. Comprehensive understanding of axon neurobiology, from molecule to theory, is a critical step towards understanding logic of signal processing in the brain. Several aspects of axon neurobiology is envisaged from AIS organization & development to structural and functional plasticity through control of axonal propagation. Despite the difficulty in the analysis of axon physiology due to the small size of the axon, recent methodological advance enabled analysis of the structure and function of axons on a fine scale.
In this Research Topic, we will highlight recent progress in axon research from various experimental approaches. These will include subcellular patch-clamp recording from axons or axon terminals, computational simulation based on realistic axon model, voltage- and calcium-imaging, molecular biology, cell biology and super resolution confocal imaging. We aimed to shed light on the fact that CNS axons are regulated much dynamically than previously thought. Any type of contribution, including original research, review, and perspective on this topic is welcome.
Keywords: action potential, axon, excitability, modeling, subcellular recording
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.