Research Topic

Axon Neurobiology: Fine-Scale Dynamics of Microstructure and Function

About this Research Topic

The axon represents the main output structure of neurons. It carries neuronal information under the form of action potentials from the site of initiation at the axon initial segment (AIS) to the terminal located in some cases at several centimeters without attenuation. Comprehensive understanding of axon neurobiology, from molecule to theory, is a critical step towards understanding logic of signal processing in the brain. Several aspects of axon neurobiology is envisaged from AIS organization & development to structural and functional plasticity through control of axonal propagation. Despite the difficulty in the analysis of axon physiology due to the small size of the axon, recent methodological advance enabled analysis of the structure and function of axons on a fine scale.

In this Research Topic, we will highlight recent progress in axon research from various experimental approaches. These will include subcellular patch-clamp recording from axons or axon terminals, computational simulation based on realistic axon model, voltage- and calcium-imaging, molecular biology, cell biology and super resolution confocal imaging. We aimed to shed light on the fact that CNS axons are regulated much dynamically than previously thought. Any type of contribution, including original research, review, and perspective on this topic is welcome.


Keywords: action potential, axon, excitability, modeling, subcellular recording


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The axon represents the main output structure of neurons. It carries neuronal information under the form of action potentials from the site of initiation at the axon initial segment (AIS) to the terminal located in some cases at several centimeters without attenuation. Comprehensive understanding of axon neurobiology, from molecule to theory, is a critical step towards understanding logic of signal processing in the brain. Several aspects of axon neurobiology is envisaged from AIS organization & development to structural and functional plasticity through control of axonal propagation. Despite the difficulty in the analysis of axon physiology due to the small size of the axon, recent methodological advance enabled analysis of the structure and function of axons on a fine scale.

In this Research Topic, we will highlight recent progress in axon research from various experimental approaches. These will include subcellular patch-clamp recording from axons or axon terminals, computational simulation based on realistic axon model, voltage- and calcium-imaging, molecular biology, cell biology and super resolution confocal imaging. We aimed to shed light on the fact that CNS axons are regulated much dynamically than previously thought. Any type of contribution, including original research, review, and perspective on this topic is welcome.


Keywords: action potential, axon, excitability, modeling, subcellular recording


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

28 February 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

28 February 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);