Axon Neurobiology: Fine-Scale Dynamics of Microstructure and Function

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Editorial

23 September 2020

Editorial: Axon Neurobiology: Fine-Scale Dynamics of Microstructure and Function

Haruyuki Kamiya

and

Dominique Debanne

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Haruyuki Kamiya

Graduate School of Medicine, Hokkaido University

Dominique Debanne

Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS)

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The axon represents the main output structure of neurons. It carries neuronal information under the form of action potentials from the site of initiation at the axon initial segment (AIS) to the terminal located in some cases at several centimeters without attenuation. Comprehensive understanding of axon neurobiology, from molecule to theory, is a critical step towards understanding logic of signal processing in the brain. Several aspects of axon neurobiology is envisaged from AIS organization & development to structural and functional plasticity through control of axonal propagation. Despite the difficulty in the analysis of axon physiology due to the small size of the axon, recent methodological advance enabled analysis of the structure and function of axons on a fine scale.

In this Research Topic, we will highlight recent progress in axon research from various experimental approaches. These will include subcellular patch-clamp recording from axons or axon terminals, computational simulation based on realistic axon model, voltage- and calcium-imaging, molecular biology, cell biology and super resolution confocal imaging. We aimed to shed light on the fact that CNS axons are regulated much dynamically than previously thought. Any type of contribution, including original research, review, and perspective on this topic is welcome.

The axon represents the main output structure of neurons. It carries neuronal information under the form of action potentials from the site of initiation at the axon initial segment (AIS) to the terminal located in some cases at several centimeters without attenuation. Comprehensive understanding of axon neurobiology, from molecule to theory, is a critical step towards understanding logic of signal processing in the brain. Several aspects of axon neurobiology is envisaged from AIS organization & development to structural and functional plasticity through control of axonal propagation. Despite the difficulty in the analysis of axon physiology due to the small size of the axon, recent methodological advance enabled analysis of the structure and function of axons on a fine scale.

In this Research Topic, we will highlight recent progress in axon research from various experimental approaches. These will include subcellular patch-clamp recording from axons or axon terminals, computational simulation based on realistic axon model, voltage- and calcium-imaging, molecular biology, cell biology and super resolution confocal imaging. We aimed to shed light on the fact that CNS axons are regulated much dynamically than previously thought. Any type of contribution, including original research, review, and perspective on this topic is welcome.

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Editors

Haruyuki Kamiya

Graduate School of Medicine, Hokkaido University

Dominique Debanne

Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS)

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124,321 Article views

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Frontiers in Cellular Neuroscience

Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

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