Research Topic

Male Fertility Biomarkers

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The accurate prediction of male fertility is of major economic importance in the livestock breeding industry, especially in the bovine because semen from one bull is used to artificially breed several thousands of female. Using semen from low-fertile bulls leads to colossal loss to the farming community in ...

The accurate prediction of male fertility is of major economic importance in the livestock breeding industry, especially in the bovine because semen from one bull is used to artificially breed several thousands of female. Using semen from low-fertile bulls leads to colossal loss to the farming community in terms of conception failure and reduced life-time reproductive efficiency of females. Low-fertile males can be identified at a very later stage only, upon large scale use of semen samples through artificial insemination and subsequent feedback from the field, substantially hampering the genetic gain. Now it is well understood that conventional semen analysis has limited value in prediction of male fertility. Consequently, several tests using specific fluorescent probes have been developed and used to identify sperm functional differences between high- and low-fertile males. Although these tests give an idea about the functional competence of spermatozoa and indicate their fertilizing potential, to some extent, their usefulness in male fertility prediction is limited and results are not consistent.

Recent developments in “OMICS” including genomics, transcriptomics, proteomics and metabolomics techniques may hold the key to more accurate identification of male fertility markers. These approaches have been gaining importance in andrological studies in humans and animals for understanding the biological mechanisms of sperm function and its interaction with oocyte. The comprehensive understanding of the bio-molecules in spermatozoa and seminal plasma is essential to reveal functionally important molecules, their interactions and various physiological mechanisms involved in fertilization process.

Increasing demand for development of male fertility prediction tools coupled with advancements in scientific techniques led to generation of a lot of information on this aspect at several laboratories across the globe as witnessed by increasing number of publications on this aspect. However, precise determination of male fertility still remains elusive. Bringing together the findings of the researchers working in the area of male fertility by providing a suitable platform for publication of their salient findings and facilitating discussion among peer researchers is expected to facilitate thorough understanding of male fertility and for identification of suitable male fertility marker(s).

The scope of the research topic include molecular differences in spermatozoa and seminal plasma between fertile and infertile males. Manuscripts on sperm phenotypic differences in relation to male fertility are also welcome. Although the topic is mostly concerned with livestock, significant findings on men fertility that could be extrapolated to livestock species are also within the scope of the research topic. We are interested in systematic reviews and original research articles. The priority area include, but not limited to, genomics, transcriptomics, protemoics and metabolimics study in relation to male fertility. Only those manuscripts which are original, have not been published elsewhere, and are not currently being considered for inclusion in another publication will be considered for publication.


Keywords: Fertility, sperm proteins, transcripts, metabolites, sperm phenotypes


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