About this Research Topic
Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed.
Some specific topics could be, but are not limited to the following:
1. Apply a novel design or approach to analyze complex traits with family data or both family and population data to identify causal genetic variants, environmental risk factors, as well their interactions
2. Predict disease risk using family data by integrating genetic, environmental and clinical information
3. New design and analysis approaches for using sequencing technology in family data to identify disease-associated variants for complex disorders
4. Insight review on the studies and methods to analyze family data in genetic epidemiology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.