About this Research Topic
Exosomes are nanosized bodies secreted by different types of cells. Fast increasing evidences have shown that exosomes are associated with various physiological and pathological events, and it has been widely accepted that exosomes can be applied both for prognostic and for therapeutic purposes. Further investigations on exosomes in oral pathology and oral physiology will be helpful to define the general role of a novel research field, named “exosome theranostics”, in the specific clinical field of oral medicine.
In dentistry, modern biomedical approaches have significantly advanced new prognostic and therapeutic pathways. Nowadays, molecular biology and physiology have been successfully integrated into everyday dental practice such as pulp regeneration, dental implantology and bone preservation. Particularly, recent progresses on the knowledge of biological significance of small intracellular bodies or intranuclear nano-particles, both also frequently found in extracellular liquids, have essentially improved oral cancer prevention and early diagnosis.
Exosomes contain proteins, nucleic acids, lipids, and microRNAs and can be derived from many oral-derived cells including oral and dental stem cells as well as tumor cells. Moreover, saliva is enriched with exosomes. In addition, exosomes have been proved being able to transport various messengers between different oral-dental cell types.
The aim of this Research Topic is to provide the international dental research societies the latest state-of-the-art knowledge on the application of exosome in diagnostics and prognostics or oral and dental diseases through integrating efforts from researchers from such as but not limited to molecular therapeutics, biosensors, system biology, translational medicine. We will encourage submissions reporting novel basic research, clinical outcomes and concise reviews.
Keywords: extracellular vesicles, theranostics, exosomes, oral biology, dentistry, cancer therapy, bioactive scaffolds
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