About this Research Topic
In the present Research Topic, we explore Neuroprosthetic approaches to the management of severe and up-to-day difficult to treat o even untreatable diseases and dysfunctions of the immune, neural and vascular systems.
The Topic is open but not limited to therapeutic approaches for (i) diabetic wounds, obesity, dystonia, back pain, etc. through control of the Vagus and Trigeminal Nerves (ii) control and modulation of neuroprotective and neuroregenerative pathways in brain injuries or neurodegenerative diseases like hemorrhagic stroke, traumatic brain injury, Parkinson disease, etc. (iii) Vagus Nerve Stimulation for the modulation of the immune system with particular emphasis on the control of autoimmune diseases.
This last field is of particular interest since Vagus Nerve is a central component of the cholinergic anti-inflammatory pathways through which the brain modulates systemic inflammatory responses. Vagal afferent fibers are able to detect peripheral immune-related events, to relay this information to the nucleus of the solitary tract and to generate autonomic, endocrine and behavioral responses via central reflex pathways.
Contributions can focus indistinctively on scientific, methodological, technological or clinical aspects. Minimally- and non-invasive Neuroprosthetic approaches are extremely relevant for this Research Topic for the obvious advantages they offer for easy and massive use in clinics with consequent health, social and economic benefits.
Are very welcome:
1. Original research papers reporting results from animal or human experiments but also from in-vitro, 3D organotypic cultures or computational studies.
2. Clinical trials, successful or not, but with a critical discussion of the results, especially if they are negative
3. Exhaustive comprehensive reviews with a critical discussion of the state-of-the-art of a specific application/disease
4. Theoretical and speculative papers for futuristic applications
5. White papers
6. Single cases reports if they provide significant information/data to open a new debate or research line
Authors should take into account that their papers have to be comprehended by scientists, engineers and clinicians from multiple disciplines, which are normally very interested, but they lack the specific knowledge.
Topic Editor Eugenijus Kaniusas is co-founder and CTO of SzeleSTIM GmbH. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.