About this Research Topic
Common neuroendocrine axes comprise the hypothalamus-pituitary gland and corresponding target organs, as for example the hypothalamus–pituitary–adrenal (HPA) axis, the hypothalamus–pituitary–thyroid (HPT) axis, the hypothalamus–pituitary–gonadal (HPG) axis, the hypothalamus–neurohypophyseal (HN) axis, the hypothalamus-pituitary-liver (HPL) axis, the hypothalamus-pituitary-prolactin (HPP) axis and the hypothalamus-pituitary-growth hormone (HPGH) axis.
Among the immune circuits, cytokines/chemokines are distinguished by their immunomodulatory actions on neuroendocrine circuits. Cytokines regulate endocrine responses such as by stimulating the HPA axis and adipose tissue or suppressing the HPT, HPG and HPP axes. In contrast, disruption of neuroendocrine circuits can lead to alterations in many critical aspects of immunity - such as thymus-derived T cell development and function and interactions between lymphocytes and micro-environmental cells in thymus, spleen and lymph nodes. Due to the high diversity of interactions between neuroendocrine and immune circuits, the imbalance of these components of neuro-immune-endocrine system leads to development and/or exacerbation of several diseases.
With this Research Topic we welcome investigators to submit original research articles as well as review articles that aim to increase our knowledge about neuroendocrine-immunology in conditions of homeostasis and disease, as well as the potential effects of diverse therapeutics agents on these circuits.
Potential topics include, but are not limited to:
i) Cross-talk between the neuroendocrine and immune systems in health and disease;
ii) Effects of immunomodulatory agents on hormone production; and
iii) Effects of therapeutic agents on neuroendocrine and/or immune circuits in health and disease.
Keywords: Neuro-endocrine Interactions, Immunoendocrine Interactions, Hormone Production, Chronic Diseases, Inflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.