Research Topic

Hypertension and the Brain

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About this Research Topic

Hypertension remains the leading cause of stroke and the third cause of disability. There is growing evidence that hypertension is related not only to stroke, but also to subclinical brain damage and cognitive dysfunction, and that increased arterial stiffness and microvascular dysfunction might be the ...

Hypertension remains the leading cause of stroke and the third cause of disability. There is growing evidence that hypertension is related not only to stroke, but also to subclinical brain damage and cognitive dysfunction, and that increased arterial stiffness and microvascular dysfunction might be the mechanism underlying this link. This relationship might be further influenced by neuroinflammation, sympathetic nervous system overactivity and the presence of obstructive sleep apnea. Furthermore, there is compelling precedent for supposing that local cerebrovascular dysfunction and altered neuroanatomical connectivity predispose to development/progression of hypertension and to accelerated brain aging.

Rapid development of novel methods assessing cerebrovascular function, neuroanatomical connectivity and cardiovascular regulation might provide new insights into pathogenesis of hypertension, stroke and other cardiovascular diseases. There is a clear-cut need for closer integration of disciplines such as cardiology, neurology, neuropsychology and radiology.

The scope of this Research Topic is to improve our current understanding of the relationship between hypertension and the brain, in the effort to help the field move forward.

The authors are encouraged to provide original scientific papers and up-to-date reviews focused on both basic and clinical studies. Potential topics include, but are not limited to: primary and secondary stroke prevention, acute stroke management, hypertension-related cognitive dysfunction, new mechanisms underlying subclinical brain damage, sympathetic neural mechanisms, brain imaging and novel therapies.


Keywords: Brain, Cognition, Hypertension, Stroke, Sympathetic Nervous System


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