About this Research Topic
This Research Topic aims to understand the influence of microbes on brain health. The gastrointestinal system hosts more than 10,000 classes of bacteria of about 1,800 distinct phyla. Interestingly, these microbiota are able to influence brain function and development. For instance, microbiota can influence the brain by modulating immune responses. Hereby, the activation of the immune system and/or the release of mediators that are able to cross the blood brain barrier plays an important role.
In addition to the contribution of microbiota to gastrointestinal and blood brain barrier integrity, inflammatory mechanisms recently became a focus of attention in this field of research. Microbiota-derived metabolites and antigens directly influence the development and function of the host immune system. Also, multidirectional interactions between the immune system, enteric nervous system and intestinal barrier function exist and seem to be microbiota-dependent.
Although the composition of the gut microbiota varies between individuals, marked changes have been recorded in individuals affected by certain brain disorders. Recent years have seen important progress in the understanding of gut-brain interactions. Given that microbial dysbiosis is a shared factor for several brain disorders, targeting microbiota composition and inflammation for the development of novel treatments is a rapidly emerging field of neuroscience research.
A multidisciplinary approach is needed to clarify the role of inflammation and nervous system function in disease. Clarifying interactions of commensal microbes with the host nervous system will expand the understanding of basic biology, disease processes and potentially identify novel treatment approaches.
This Research Topic welcomes manuscripts elaborating on the roles of microbes and inflammation in neurological disease, interactions between the gut nervous system and bacteria, research pertaining to gut-brain axis interactions, peripheral mechanisms in central nervous system disorders and contributions of neural inputs to inflammatory disease. We welcome original research in cellular and animal models, clinical studies and Reviews of the literature in research fields relevant to nervous system disorders and microbial dysbiosis.
Keywords: Inflammation, Microbes, neurological disease, brain, gastrointestinal tract
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.