Research Topic

Antioxidants, Medicinal Plants, Phytonutrients, and Cancer Risk

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About this Research Topic

Clinical and epidemiological studies continue to support the notion that cancer is a dieatry-related syndrome in which oxidative stress is a cofactor. Dietary antioxidants deficiencies and low intake of phytonutrients are involved in the pathogenesis of oxidative stress and its associated carcinogenesis. ...

Clinical and epidemiological studies continue to support the notion that cancer is a dieatry-related syndrome in which oxidative stress is a cofactor. Dietary antioxidants deficiencies and low intake of phytonutrients are involved in the pathogenesis of oxidative stress and its associated carcinogenesis. Medicinal plants are thought to be associated with the reduction of oxidative stress by combating environmental oxidizing agents and cellular insults in a mechanism involves the homeostasis of cellular redox signaling pathways.

The general goal for this Research Topic is to provide a therapeutic insight into the protective role of dietary bioactive agents against oxidative stress-mediated carcinogenesis. The specific aims are to tackle: (1) Metabolic modulation of oxidative stress-mediated carcinogenesis; (2) Mechanisms of action and genes involved in the etiology of cancer; (3) The regulatory role of B vitamins and glutathione in relation to DNA methylation.

This Research Topic will be a collection of articles (Research Articles, Case Reports, Hypothesis and review Articles) based on the following themes:

 Nutritional deficiencies of antioxidants and phytonutrients in relation cancer risk.
 Oxidative stress-mediated carcinogenesis and its related signaling pathways in experimental models and human clinical trials.
 Therapeutic role of herbs and medicinal plants against cancer.
 The innovative role functional foods and nutraceuticals in combating cancer.


Keywords: Antioxidants, phytonutrients, cancer risk, oxidative stress, Medicinal plants


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