Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome

206.2K

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50

authors

13

articles

Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome

206.2K

views

50

authors

13

articles

Editorial

31 July 2014

How Traumatic Experiences Leave Their Signature on the Genome: An Overview of Epigenetic Pathways in PTSD

Tania L. Roth

25,348 views

10 citations

Editors

3

Tania L Roth

University of Delaware

David M Diamond

University of South Florida

Karestan Koenen

School of Public Health, Harvard University

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Epidemiological evidence supports a role for gene-environmental interactions in post-traumatic stress disorder (PTSD). Because environmental exposure to trauma is an etiological factor necessary for the development of PTSD, understanding the molecular mechanisms by which genes respond to traumatic stress may provide insight into the development and life-long persistence of PTSD symptoms. Emerging evidence suggests that DNA methylation, histone modifications, noncoding RNA regulation, and alternative splicing of mRNA provide an epigenetic means by which chronic stress and traumatic experiences alter gene expression to produce long-term changes in neuroanatomy, physiology and behavior. This research topic will focus on epigenetic components of PTSD, and highlight translational research including common measures and outcomes of stress and trauma found in animal, civilian and military research. We will also consider observational and epidemiologic studies that support epigenetic transmission of stress-related phenotypes. We aim to provide a forum for experts in the field to present novel research findings, methodology, opinions, hypotheses and critical reviews that address how traumatic stress interacts with the genome.

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Editors

Tania L Roth

University of Delaware

David M Diamond

University of South Florida

Karestan Koenen

School of Public Health, Harvard University

Impact

206,235 Total views

152,008 Article views

37,896 Article downloads

16,331 Topic views

Published In

Frontiers in Psychiatry

Molecular Psychiatry

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