About this Research Topic
Studies on signalling pathways have proven insightful in improving our understanding of development and disease. The Hippo signalling pathway has garnered much attention due to its ability to control stem cell behaviour, organ size and tumorigenesis. Hippo signalling activity is responsive to changes in cell adhesion, polarity, mechanical forces, metabolism, and secreted ligands. Importantly, the Hippo signalling pathway is also known to be significantly impacted in many human diseases, including eye -, cardiovascular- and neuronal- diseases, besides cancer.
Yki/YAP addiction is now emerging as a central property of cancers that may be targeted for therapy. However, there remain key gaps in our understanding of the molecular mechanisms by which diverse inputs are integrated to impact Yki/YAP activity and Yki/YAP-regulated transcriptional targets are selected. Thus, it is important to review recent advances, and emerging hypotheses and new perspectives on the mechanisms and regulatory interactions that impact Yki activity, to achieve a better understanding of the significance of these interactions in development and disease.
In this Research Topic, we call for reviews, research articles and perspectives/ commentaries focused on mechanisms of Yki/YAP regulation via upstream stimulators or its interactions with other signalling pathways in a developmental (e.g., model – or tissue-specific) or disease context.
Complexities regarding the regulation of the Hippo pathway are now emerging, as illustrated by the vast differences in the mechanisms of Yki/YAP regulation under homeostatic conditions and in disease pathologies. These differences demonstrate the vast array of signalling and other interactions that impact Hippo pathway regulation.
Contributions to this Research Topic will help to clarify the molecular mechanisms involved in Hippo pathway regulation – an area of interest to diverse groups of scientists, including academics [developmental biologists, cancer biologists, stem cell biologists, cell biologists], clinicians [physician scientists from different disciplines including but not limited to Oncology, Cardiology, etc.] and pharmacologists; and students working in these areas.
Keywords: Hippo, signalling, YAP, Yki, cancer