Research Topic

Clinical Expression of Endocrine Disruptors in Children

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About this Research Topic

In recent years, significant and scientific information has been published on the connection between chemical endocrine disruptors and diseases or disorders in children. These Environmental Disruptors Chemicals (EDCs), such as pesticides (organophosphate insecticides, glyphosate, dioxins), plastics (bisphenol ...

In recent years, significant and scientific information has been published on the connection between chemical endocrine disruptors and diseases or disorders in children. These Environmental Disruptors Chemicals (EDCs), such as pesticides (organophosphate insecticides, glyphosate, dioxins), plastics (bisphenol A, phthalates), chemicals substances (PCB, PDPE, PFOA, parabens, etc.), heavy metals and nanoparticles, present in the air, water, nutriments, household products, cosmetics, drugs and so on, impact normal fetal development and cause lifelong damages reinforcing the new concept of the fetal origin of adult diseases.

The responsibility of EDCs in the alarming-rise of endocrine diseases and disorders such as genital malformations in the male new-borns, intrauterine growth retardation, neurodevelopmental disorders, obesity, precocious puberty in the girls, diabetes, etc.; over the last two decades raised several concerns among not only paediatricians, but also obstetricians, endocrinologists, epidemiologists and public health specialists. This worldwide sanitary scandal became also a strong matter of concern among economists, ethicists and justice experts.

This Research Topic of Frontiers in Endocrinology covers for the first time the most frequent paediatric endocrine diseases, related to EDCs. Each review is covered by an expert in this field.

We hope this Topic will become an indispensable tool for professionals to manage these new aspects of paediatric endocrinology and will help to minimize the consequences of EDCs exposure of the fetus, infant and child.

Sub-themes of the current issue include, but are not limited to:

• The fetus, a target for endocrine disruptors
• DES, a model for the study of EDCs
• Disorders of sex determination in the male new-borns
• Intra-uterine growth retardation
• Hypothyroidism
• Neurodevelopmental disorders
• Obesity
• Precocious puberty in girls
• Mechanism of action of EDCs
• How to evaluate EDCs contamination?
• The cocktail effect of EDCs
• Financial concerns


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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