Research Topic

Interplay between Oncogenes and Oncometabolism: From Basic Mechanisms to Novel Future Treatment Paradigms

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About this Research Topic

Cancer is a complex disease with multifaced mechanism including genetic mutations and metabolic alteration. Oncogenes are key players in cancer progression and development. Hanahan and Weinberg in 2011 categorized “tumor metabolism” and “genetic aberrations” as “Hallmarks of Cancer”. Thus, there is a great ...

Cancer is a complex disease with multifaced mechanism including genetic mutations and metabolic alteration. Oncogenes are key players in cancer progression and development. Hanahan and Weinberg in 2011 categorized “tumor metabolism” and “genetic aberrations” as “Hallmarks of Cancer”. Thus, there is a great need to understand how metabolism is regulated in cancer to fulfill energy demand of hyper proliferative cells.

Some of the molecular drivers like oncogenes have been repeatedly demonstrated to influence cell death, growth and metabolic pathways of a pre-cancer or cancer cell. The challenge is to understand how these molecular drivers differ from their function in normal cells and in homeostatic regulation. If key molecular drivers of cancer can be identified, novel therapies can be obtained to selectively kill cancer cells.

This Research Topic on the “Interplay of Oncogenes and Oncometabolism” will provide an open-source sharing significant articles describing the role for new and emerging players in regulating cancer and how these players may impinge on the cell death, metabolic and growth characteristics of a pre-cancer or cancer cell.

Sub-Themes of this Research Topic include, but are not limited to:
• The use of Organoids to explore the cross-talk between Oncogenes and Metabolism;
• Targeting tumor metabolism by small molecules in cancer therapy;
• The relationship between Oncometabolism and Oncogene cell signals;
• Tumor metabolism as a driver of development of hematologic malignancies;
• Roles for oncogenes in modulating energy metabolism in cancer;
• Understanding the interplay between oncogenes cells signals and metabolism in cancer progression;
• Developing an understanding for where the treatment options are currently seen in these fields;
• Learning what is presently developed preclinically and what is already undergoing within clinical trials in relations to oncogene and metabolism;
• Discovering where the opportunities for the future lie, both with respect of mechanistic insight and treatment options for cancer affected by dysregulated genes and metabolism.


Keywords: Oncogene, Tumor metabolism, Cell death, Metabolic Pathways


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