Hard Problems | List of Frontiers open access articles

Original Research

Accepted on 02 Mar 2026

Soybean oil and leucine in late gestation and lactation improve maternal and offspring lipid metabolism and insulin sensitivity: Insights from pig model

in Animal Nutrition and Metabolism

Yutong Sun
Zexuan Gan
Xueyuan Li
Yuxin Lin
Xinbo Zhou
Qingquan Ma

Frontiers in Veterinary Science

Original Research

Accepted on 02 Mar 2026

Enhancing the Knowledge and Understanding Domain of Physical Literacy: Instrument Validation and a Kahoot-Supported Intervention in Physical Education

in Physical Education and Pedagogy

Bogdan Sorin Olaru
Iconomescu Teodora Mihaela
Laurentiu-Gabriel Talaghir

Frontiers in Sports and Active Living

Review

Accepted on 02 Mar 2026

Linking Inflammation, Metabolic Dysfunction, and Neurodegeneration: A Comprehensive Review of TLR2 Pathways in Type 2 Diabetes

in Diabetes Multiorgan Complications

JUAN ARREGUIN-CANO
Sandra Aidé Santana-Delgado
Carlos Esteban Villegas
Grissel Guadalupe Orozco-Molina
Adolfo González-Acosta
Mercedes Bermúdez

Frontiers in Clinical Diabetes and Healthcare

Original Research

Accepted on 02 Mar 2026

Association Between C-Reactive Protein to Albumin Ratio and Major Adverse Cardiac Events in Patients with Stable Coronary Artery Disease Treated by Percutaneous Coronary Intervention

in Coronary Artery Disease

Zhiye Zou
Kai Lai
Shuiqing Gui
Xisi He

Frontiers in Cardiovascular Medicine

Systematic Review

Accepted on 02 Mar 2026

Periodontal Disease and Obstructive Sleep Apnea: An Umbrella Review

in Oral Epidemiology

Franz Tito Coronel-Zubiate
Carlos Alberto Farje-Gallardo
Paul Martín Herrera Plasencia
Teresa Etelvina Ríos-Caro
Sonia Tejada-Muñoz
Betsy Quispe
Rubén Aguirre
Heber Isac Arbildo-Vega

Frontiers in Oral Health

Original Research

Accepted on 02 Mar 2026

Influence of a sport-oriented exercise concept on motor performance and sustainability in healthy but sporting inactive older adults aged 60+

in Physical Activity in the Prevention and Management of Disease

Anneke Schumacher
Marlene Krumpolt
Lucas Sannemann
Kerstin Witte

Frontiers in Sports and Active Living

Case Report

Accepted on 02 Mar 2026

Ultrasonographic Diagnosis of Pure Inversion of Meckel's Diverticulum Without Obstruction in a Child: A Case Report and Literature Review

in Gastroenterology

Shasha Chen
Xingxing Duan
Yunfang Zhu
Rong Tian
Hongxia Yuan

Frontiers in Medicine

Original Research

Accepted on 02 Mar 2026

Primary school physical activity culture in the UK: Findings from a four-month rapid ethnography in three schools

in Children and Health

Robert Walker
Lydia Emm-Collison
Danielle House
Simona Kent-Saisch
Ruth Salway
Alice Porter
Abi Howard
Tom Reid
Michael Beets
Frank de Vocht

Frontiers in Public Health

Review

Accepted on 02 Mar 2026

Transition Metal Complexes with Asymmetric Tridentate Peripheral Organosilyl Ligands: Their Impact in Homogeneous Catalysis

in Organometallic Chemistry

Francisco José Fernández-Alvarez
María Batuecas
Luis A. ORO

Frontiers in Chemistry

Original Research

Accepted on 02 Mar 2026

Depression Subtype Classification from Social Media Posts: Few-Shot Prompting vs Fine-Tuning of Large Language Models

in Digital Mental Health

Rawan AlSaad
Sulaiman Alshakhs
Rajat Thomas

Frontiers in Digital Health

Opinion

Accepted on 02 Mar 2026

The Role of Causal Reasoning and Directed Acyclic Graphs in Multivariable Regression: Implications for Evidence-Based Veterinary Medicine

in Anesthesiology and Animal Pain Management

Pablo A Donati
Felipe J Lillo-Araya
Valdora Valdora
Pablo E Otero

Frontiers in Veterinary Science

Original Research

Accepted on 02 Mar 2026

Latent profile analysis of self-efficacy in information security and positive coping level among nursing students: A multicenter cross-sectional study in China

in Health Psychology

Yingxue Niu
Shiming Chen
Min Hu
Yifang Li

Frontiers in Psychology

Systematic Review

Accepted on 02 Mar 2026

The Efficacy and Safety of Transcranial Direct Current Stimulation in Patients with ADHD: A Systematic Review and Meta-Analysis

in ADHD

Jie Li
Xinyu Hou
Qiongli Fan
Li Chen

Frontiers in Psychiatry

Original Research

Accepted on 02 Mar 2026

Critical Skills: Qualitative content analysis of medical residents in social skills training with RPGs

in Health Psychology

Victor Henrique Oyamada Otani
Rafael Condoretti Novaes
Julia Pedron
Pedro Chen Nabhan
Thaísa Malbar Rodrigues
Ryo Chiba
Henrique do Amaral Duarte
João Vitor Guedes
Felipe Oliveira de Aguiar
Lucas Murrins Marques

Frontiers in Psychology

Original Research

Accepted on 02 Mar 2026

Effects of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou Seed Mixture on Sleep Quality in Pre-clinical and Clinical Studies

in Food Biotechnology

Juhui Choe
Youn Woo Lee
Eunyeong Byeon
Yu Jin Hwang
Yeong Ro Lee

Frontiers in Food Science and Technology

Original Research

Accepted on 02 Mar 2026

Building Australia's non-animal technologies ecosystem: a national cross-sector mapping and strategic insights from the Non-Animal Technologies Network (NAT-Net)

in In Vitro Toxicology

Shafagh A Waters
Adam Hill
Esther Pronker
Gerard Kaiko
Gungun Lin
Simon Keely
Laura Collie
Wojciech Chrzanowski
Anai Gonzalez Cordero

Frontiers in Toxicology

Articles

Soybean oil and leucine in late gestation and lactation improve maternal and offspring lipid metabolism and insulin sensitivity: Insights from pig model

Enhancing the Knowledge and Understanding Domain of Physical Literacy: Instrument Validation and a Kahoot-Supported Intervention in Physical Education

Linking Inflammation, Metabolic Dysfunction, and Neurodegeneration: A Comprehensive Review of TLR2 Pathways in Type 2 Diabetes

Association Between C-Reactive Protein to Albumin Ratio and Major Adverse Cardiac Events in Patients with Stable Coronary Artery Disease Treated by Percutaneous Coronary Intervention

Periodontal Disease and Obstructive Sleep Apnea: An Umbrella Review

Influence of a sport-oriented exercise concept on motor performance and sustainability in healthy but sporting inactive older adults aged 60+

Ultrasonographic Diagnosis of Pure Inversion of Meckel's Diverticulum Without Obstruction in a Child: A Case Report and Literature Review

Primary school physical activity culture in the UK: Findings from a four-month rapid ethnography in three schools

Transition Metal Complexes with Asymmetric Tridentate Peripheral Organosilyl Ligands: Their Impact in Homogeneous Catalysis

Depression Subtype Classification from Social Media Posts: Few-Shot Prompting vs Fine-Tuning of Large Language Models

The Role of Causal Reasoning and Directed Acyclic Graphs in Multivariable Regression: Implications for Evidence-Based Veterinary Medicine

Latent profile analysis of self-efficacy in information security and positive coping level among nursing students: A multicenter cross-sectional study in China

The Efficacy and Safety of Transcranial Direct Current Stimulation in Patients with ADHD: A Systematic Review and Meta-Analysis

Critical Skills: Qualitative content analysis of medical residents in social skills training with RPGs

Effects of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou Seed Mixture on Sleep Quality in Pre-clinical and Clinical Studies

Building Australia's non-animal technologies ecosystem: a national cross-sector mapping and strategic insights from the Non-Animal Technologies Network (NAT-Net)