Large Scale Optimization | List of Frontiers open access articles

Original Research

Accepted on 28 Feb 2026

Efficacy of Surgery Versus Definitive Chemoradiotherapy Following Neoadjuvant Chemotherapy in T4 Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Analysis

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Shiwang Wen
Hesong Wang
Xiaohan Zhao
Jingyuan Wen
Xinyi Liu
Ke Yan
Shuguang Li
Chunyang Song
Wenbin Shen

Frontiers in Oncology

Perspective

Accepted on 28 Feb 2026

Chatbots as Frontline Educators in Sexual Reproductive Health Rights: Evidence, Limitations, and Ethical Considerations

in Ethical Digital Health

Chioma Uzoma
Goldie Chukwuedo
Ejeh Isaac
Victory Uzoma
Stanley Chinedu Eneh
Felix Peace Chinyere
Oluchi Mmesoma Precious
Francisca Ogochukwu Onukansi

Frontiers in Digital Health

Mini Review

Accepted on 28 Feb 2026

Potential correlation between chronic pain and amyloid beta in Alzheimer's disease

in Neuropathic Pain

Yanying Liu
Xiao-Ping Wang

Frontiers in Pain Research

Original Research

Accepted on 28 Feb 2026

Clinical Characteristics of Mycoplasma pneumoniae pneumonia in children and construction of a severe case prediction model: A retrospective study from Yan 'an, China

in Pediatric Pulmonology

Qiaohui Zha
Huirong Li
Yuxuan Li
Hairui Gao
Yuanxia Li
Kunpeng Jia

Frontiers in Pediatrics

Review

Accepted on 28 Feb 2026

The Role of Exercise-Mediated Mitochondrial Quality Control Remodeling in Aging

in Membrane Traffic and Organelle Dynamics

Tao Cai
Yating Li
Yunsong Zhang
Chunyan Li
Shanhui Li
Qi Zhang

Frontiers in Cell and Developmental Biology

Case Report

Accepted on 28 Feb 2026

Treatment of ultra-late phrenic nerve stimulation after cardiac resynchronization therapy with double-layer spacer isolation technique

in Cardiac Rhythmology

Cai He
Wei Wang
Yue Bao
HongWei Han

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 28 Feb 2026

Integrated Molecular Dynamics Elucidation of TP53 H179 Zinc-Binding Variants: Genomic and Structural Characterization Across NSCLC Subtypes

in Genomic Analysis

Ankur Datta
George Priya Doss C

Frontiers in Bioinformatics

Original Research

Accepted on 28 Feb 2026

Synergistic Enhancement of Soybean Yield and Quality by Diethyl Aminoethyl Hexanoate(DA-6):Unraveling the Molecular Mechanisms through Integrated Transcriptomics

in Crop and Product Physiology

Qingnan Hao
chao li
shuilian chen
hongli yang
zhonglu yang
zhihui shan
haifeng chen

Frontiers in Plant Science

Original Research

Accepted on 28 Feb 2026

Rapid Establishment of KRAS-Driven Bladder Cancer Initiation and Immune Escape Models Using Genetically Engineered Mice and Organoid Approaches

in Cancer Immunity and Immunotherapy

Guoliang Yang
Yishu Wang
Zhangzhengyi Fan
Guojiang Wei
Xuqing Shen
HeJian Zhang
Mengyao Liu
Bin Yu

Frontiers in Immunology

Original Research

Accepted on 28 Feb 2026

Pediatric Infection-Triggered Encephalopathy Syndromes: A Multidimensional Biomarker Analysis

in Pediatric Neurology

Caihui Ma
Shuowen Wang
Zhijie Gao
Zijun Wang
Hui Jiao
Yizhi Zhang
Shuo Miao
Zhao Liu
Jianzhao Zhang

Frontiers in Neurology

Original Research

Accepted on 28 Feb 2026

Assessing the Farmers' Perception Towards Precision Water Application Devices Under the PMKSY Scheme: A TAM-Based Structural Equation Modelling Approach

in Field Water Management

Paul Mansingh J
Sundarambal P
Merlin Mathew
Annie Jenifer M
Nisha A
Atsu Frank Yayra Ihou
Mauli Kathule
Vetha Hanumand P L
Arunkumar K

Frontiers in Agronomy

Original Research

Accepted on 28 Feb 2026

Predictive factors and clinical outcomes following contemporary percutaneous coronary interventions for chronic total occlusions

in Coronary Artery Disease

Jin Lin
Youhu Chen
Huan Wang
Genrui Chen
Xiaolin Lei
Cai Yue
Xiang Cheng Li
Haokao Gao

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 28 Feb 2026

Safety Recommendations for ALK Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer: Evidence from FAERS and CVARDD Real-World Databases

in Pharmacology of Anti-Cancer Drugs

Yuanyuan Zhang
Tuanzhuang Zhang
Yu-ping Yang
Wenhui Zhang
Qiangping Ma
Juan Li
Jintian Li
Xuan Yang
Jirong Gong
Xinyi Wang

Frontiers in Oncology

Original Research

Accepted on 28 Feb 2026

Mm-VitnNet:A Gated Image-Text Interaction Network for Soybean Salt Tolerance Recognition Using Chlorophyll Fluorescence Phenotypes

in Sustainable and Intelligent Phytoprotection

Wenxiang Liang
Xiaoyan Zhang
Ziqiu Luo
Qingyang Li
Hao Wang
Yixin Feng
Licheng Zhao
Ziyan Lu
Xiaotian Yuan
Xiouxiou Zhou

Frontiers in Plant Science

Original Research

Accepted on 28 Feb 2026

Resident Stress Levels During Simulated Patient Encounters

in Emergency Health Services

Angela Cornelius
Charles Phillip Orr
Brad Goldman
Jaime Jordan
Eric Clifford
Urska Cvek
Marjan Trutschl
Phillip CSR Kilgore
Shane Jenks

Frontiers in Disaster and Emergency Medicine

Original Research

Accepted on 28 Feb 2026

Localized Bioimpedance Reactance as a Biophysical Parameter of Muscle Recovery Following Total Knee Arthroplasty: A Prospective Self-Controlled Study

in Exercise Physiology

Gloria Pedemonte-Parramón
Lexa Nescolarde
Ester García-Oltra
Vicente López-Pérez
Francisco Aliaga-Orduña
José A. Hernández-Hermoso

Frontiers in Physiology

Articles

Efficacy of Surgery Versus Definitive Chemoradiotherapy Following Neoadjuvant Chemotherapy in T4 Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Analysis

Chatbots as Frontline Educators in Sexual Reproductive Health Rights: Evidence, Limitations, and Ethical Considerations

Potential correlation between chronic pain and amyloid beta in Alzheimer's disease

Clinical Characteristics of Mycoplasma pneumoniae pneumonia in children and construction of a severe case prediction model: A retrospective study from Yan 'an, China

The Role of Exercise-Mediated Mitochondrial Quality Control Remodeling in Aging

Treatment of ultra-late phrenic nerve stimulation after cardiac resynchronization therapy with double-layer spacer isolation technique

Integrated Molecular Dynamics Elucidation of TP53 H179 Zinc-Binding Variants: Genomic and Structural Characterization Across NSCLC Subtypes

Synergistic Enhancement of Soybean Yield and Quality by Diethyl Aminoethyl Hexanoate(DA-6):Unraveling the Molecular Mechanisms through Integrated Transcriptomics

Rapid Establishment of KRAS-Driven Bladder Cancer Initiation and Immune Escape Models Using Genetically Engineered Mice and Organoid Approaches

Pediatric Infection-Triggered Encephalopathy Syndromes: A Multidimensional Biomarker Analysis

Assessing the Farmers' Perception Towards Precision Water Application Devices Under the PMKSY Scheme: A TAM-Based Structural Equation Modelling Approach

Predictive factors and clinical outcomes following contemporary percutaneous coronary interventions for chronic total occlusions

Safety Recommendations for ALK Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer: Evidence from FAERS and CVARDD Real-World Databases

Mm-VitnNet:A Gated Image-Text Interaction Network for Soybean Salt Tolerance Recognition Using Chlorophyll Fluorescence Phenotypes

Resident Stress Levels During Simulated Patient Encounters

Localized Bioimpedance Reactance as a Biophysical Parameter of Muscle Recovery Following Total Knee Arthroplasty: A Prospective Self-Controlled Study