Preclinical Stage | List of Frontiers open access articles

Original Research

Published on 27 Aug 2025

Type I interferons regulate nitric oxide production in Brucella abortus-activated microglia contributing to neuronal death

in Microbial Immunology

Julia Rodríguez
Alex D. Guano
Ignacio Mazzitelli
Vida A. Dennis
Ana M. Rodríguez
Guillermo H. Giambartolomei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661395

149 views

Original Research

Published on 27 Aug 2025

Comparison of Albumin-Bilirubin, Platelet-Albumin-Bilirubin, and Child-Pugh scores to predict overall survival in patients with stage C hepatocellular carcinoma with liver cirrhosis treated with c-TACE

in Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers

Fei Wu
Zhihong Zhang
Shanshan Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1613697

167 views

Case Report

Published on 27 Aug 2025

A rare case report of uterine carcinosarcoma with bilateral ovarian Brenner tumors

in Gynecological Oncology

Xinyao Wan
Fangfang Bi
Bing Xin
Chong Qiao

Frontiers in Oncology

doi 10.3389/fonc.2025.1612716

133 views

Original Research

Published on 27 Aug 2025

Exploration of the active components and mechanisms of Epimedium for the treatment of Undescended Testis

in Reproduction

Zhonglei Deng
Sirui Zhang
Haiyang Zhao
Shijia Xu
Miao Qi
Tianle Pu
Hui Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1642197

127 views

Original Research

Published on 27 Aug 2025

Association between sensitivity to thyroid hormone and prognosis in septic patients: a retrospective cohort analysis

in Thyroid Endocrinology

Jia Wang
Yingbai Wang
Zihan Xu
Chuxun Chou
Jiaofeng Xiang
Xizhi Zhang
Xuefei Hou
Suru Yue
Shicai Ye
Feng Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1611963

119 views

Review

Published on 27 Aug 2025

Pediatric inflammatory bowel disease and cancer

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Jia-Jing Zheng
Zhi-Fei Wu
Yi-Bing Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624177

179 views

Review

Published on 27 Aug 2025

Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment

in Vaccines and Molecular Therapeutics

Keda Chen
Siyi Gu
Jiaxuan Li
Yutong Xu
Zhiyi Wang
Yanjun Zhang
Jianhua Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655819

141 views

Original Research

Published on 27 Aug 2025

Innate immune dysfunction and persistent activation in South African HIV elite controllers

in Molecular Innate Immunity

Asisipo Mohamed
Yenzekile Zungu
Sharon Shalekoff
Osman Ebrahim
Ziyaad Waja
Neil Martinson
Caroline T. Tiemessen
Christina Thobakgale

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603436

213 views

Case Report

Published on 27 Aug 2025

Two case reports of renal-splenic disease presenting as renal tumors or metastases, with a literature review

in Surgical Oncology

Lijing Xu
Jialin Wang
Guangxi Sun
Hao Zeng

Frontiers in Oncology

doi 10.3389/fonc.2025.1551601

104 views

Editorial

Published on 27 Aug 2025

Editorial: Commending 20 years since the formal discovery of immune priming: the innate immune memory

in Comparative Immunology

Jorge Contreras-Garduño
Joachim Kurtz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652666

148 views

Original Research

Published on 27 Aug 2025

Biparametric MRI-based radiomics for differentiating clinically significant prostate cancer among prostate-specific antigen level of gray zone

in Genitourinary Oncology

Yugang Ji
Wei Liu
Houdong Liu
Jing Wen

Frontiers in Oncology

doi 10.3389/fonc.2025.1615005

108 views

Original Research

Published on 27 Aug 2025

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

in Molecular and Cellular Oncology

Sofia Morazzo
Soraia Fernandes
Marina Fortea
Helena Skálová
Daniel Pereira-Sousa
Marco Cassani
Kamila Vrzalová
Filip Kafka
Jan Vrbský
Mathilde Soulez

Frontiers in Oncology

doi 10.3389/fonc.2025.1563969

269 views

Mini Review

Published on 27 Aug 2025

Emerging perspectives on once-weekly insulins in type 1 and type 2 diabetes: a mini-review

in Clinical Diabetes

Damien Denimal

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1656884

473 views

Brief Research Report

Published on 27 Aug 2025

The prognostic value of health-related quality of life for early molecular response in patients with chronic myeloid leukemia: analysis of the GIMEMA-SUSTRENIM trial

in Hematologic Malignancies

Fabio Efficace
Laura Cannella
Isabella Capodanno
Rosaria Sancetta
Veronica Porcu
Monia Lunghi
Annalisa Biagi
Fausto Castagnetti
Giovanni Caocci
Thomas Baldi

Frontiers in Oncology

doi 10.3389/fonc.2025.1645217

116 views

Original Research

Published on 27 Aug 2025

A rapid antigen test to detect adenosine deaminase 2 (ADA2) in biological fluids and its application in clinical diagnostics

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Weiping Yang
Qing Zhou
Jose M. Porcel
Jun Wang
Chengxiang Wu
Andrey V. Zavialov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633219

229 views

Systematic Review

Published on 27 Aug 2025

Correlation of serum irisin levels with diabetic nephropathy: an exhaustive systematic appraisal and meta-analytical investigation

in Clinical Diabetes

Yuan Deng
Yinhui Shen
Yuchen Wu
Min Wen
Fang Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1599423

143 views

Articles

Type I interferons regulate nitric oxide production in Brucella abortus-activated microglia contributing to neuronal death

Comparison of Albumin-Bilirubin, Platelet-Albumin-Bilirubin, and Child-Pugh scores to predict overall survival in patients with stage C hepatocellular carcinoma with liver cirrhosis treated with c-TACE

A rare case report of uterine carcinosarcoma with bilateral ovarian Brenner tumors

Exploration of the active components and mechanisms of Epimedium for the treatment of Undescended Testis

Association between sensitivity to thyroid hormone and prognosis in septic patients: a retrospective cohort analysis

Pediatric inflammatory bowel disease and cancer

Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment

Innate immune dysfunction and persistent activation in South African HIV elite controllers

Two case reports of renal-splenic disease presenting as renal tumors or metastases, with a literature review

Editorial: Commending 20 years since the formal discovery of immune priming: the innate immune memory

Biparametric MRI-based radiomics for differentiating clinically significant prostate cancer among prostate-specific antigen level of gray zone

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

Emerging perspectives on once-weekly insulins in type 1 and type 2 diabetes: a mini-review

The prognostic value of health-related quality of life for early molecular response in patients with chronic myeloid leukemia: analysis of the GIMEMA-SUSTRENIM trial

A rapid antigen test to detect adenosine deaminase 2 (ADA2) in biological fluids and its application in clinical diagnostics

Correlation of serum irisin levels with diabetic nephropathy: an exhaustive systematic appraisal and meta-analytical investigation