Research Problems | List of Frontiers open access articles

Original Research

Published on 04 Mar 2026

Antibody elution methods for multiplex immunofluorescence of Alzheimer's disease pathology in human post-mortem brain tissue

in Dementia and Neurodegenerative Diseases

Dhiraj Maskey
Hoang-Tuong Nguyen-Hao
Caine C. Smith
Mario Novelli
Julia Stevens
Greg T. Sutherland

Frontiers in Neurology

doi 10.3389/fneur.2026.1760600

133 views

Original Research

Published on 04 Mar 2026

A real-world comparison study of the efficacy of dual-target first-line rescue treatment of human epidermal growth factor receptor 2 positive advanced breast cancer: trastuzumab combined with pertuzumab versus trastuzumab combined with pyrotinib

in Breast Cancer

Liang Zhang
Chao Li
Shubin Song
Fukai Wang
Tingting Ding
Zhengrui Liu
Yuqin Jin
Zhiyong Yu

Frontiers in Oncology

doi 10.3389/fonc.2026.1720851

Original Research

Published on 04 Mar 2026

Predicting cardiovascular events in hemodialysis patients based on the fusion of physicochemical indicators and tongue images: a prospective and multicenter study

in Computational Physiology and Medicine

Kun Zou
Fan Xiao
Shuang Cheng
Qingxiang Wang
Xiaohua He
Jin Wang
Lijuan Dong
Kun Bao
Wu Zhou
Daixin Zhao

Frontiers in Physiology

doi 10.3389/fphys.2026.1782190

Original Research

Published on 04 Mar 2026

Total body water to lean body mass ratio predicts mortality in patients with chronic heart failure: a prospective, observational study

in Clinical Nutrition

Linfeng Xie
Bryan Richard Sasmita
Yuhe Zhao
Jing Chen
Yuanzhu Li
Suxin Luo
Bi Huang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1762912

Original Research

Published on 04 Mar 2026

Dual-level weighted cross-entropy loss function and multi-object region segmentation network evaluation for dynamic knee joint X-ray radiography based on a novel scoring criterion

in Medical Imaging and Nuclear Medicine

Shiming Wang
Tianqi Wu
Weiqing Huang
Jinglong Du
Ziran Chen
Zhibo Xiao
Qi Gao
Yun Liu
Yingying Chen
Peng Guo

Frontiers in Medicine

doi 10.3389/fmed.2026.1768134

Brief Research Report

Published on 04 Mar 2026

Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer after prior vascular endothelial growth factor receptor-targeted therapy (COSMIC-311): outcomes by BRAF status

in Head and Neck Cancer

Marcia S. Brose
Bhumsuk Keam
Jolanta Krajewska
Ana O. Hoff
Fernanda Vaisman
Chia-Chi Lin
Erika Hitre
Daniel W. Bowles
Bruce Robinson
Steven I. Sherman

Frontiers in Oncology

doi 10.3389/fonc.2026.1748566

260 views

Original Research

Published on 04 Mar 2026

Morphological changes and lateralization of the thalamic nuclei in children with growth hormone deficiency

in Pediatric Endocrinology

Joo Young Lee
Sung-min Lim
Jung Hwan Oh
Hyuna Kim
Gang Yi Lee
Bong Gun Lee
Jeong-Kyu Hoh
Seung Yang
Hyun Ju Lee

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1678738

168 views

Original Research

Published on 04 Mar 2026

Beyond body mass index: visceral adiposity and metabolic alterations as early markers of atrial dysfunction and atrial fibrillation in midlife

in Obesity

Angelina Borizanova
Elena Kinova
Natalia Spasova
Assen Goudev

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1775534

Original Research

Published on 04 Mar 2026

Variation of the steroid profile in relation to training in women and its importance for anti-doping testing

in Exercise Physiology

A. Andersson
L. Ekström
O. Salamin
R. Nicoli
A. L. Hirschberg
E. Eklund

Frontiers in Physiology

doi 10.3389/fphys.2026.1733515

Original Research

Published on 04 Mar 2026

Comparison and excitation optimization of commercial quartz tuning forks for QEPAS

in Optics and Photonics

Lei Peng
Yihua Qian
Yaohong Zhao
Qing Wang
Yifeng Zhao
Qiang Fu

Frontiers in Physics

doi 10.3389/fphy.2026.1791440

Original Research

Published on 04 Mar 2026

Astragalus small molecules protect BMSCs from radiation-induced bystander effect and enhance lung cancer radiosensitivity via the primary cilium/TGF-βR1/Smad3 pathway

in Cancer Molecular Targets and Therapeutics

Zhiming Miao
Mengyuan Wu
Sichao Dai
Xin Wang
Yang Yang Li
Fuxian Liu
Zhiwei Liu
Liying Zhang
Yongqi Liu

Frontiers in Oncology

doi 10.3389/fonc.2026.1732029

171 views

Original Research

Published on 04 Mar 2026

Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma

in Neuro-Oncology and Neurosurgical Oncology

John McDaid
Julian E. Bailes
Neilank K. Jha
George Bobustuc
Reed Berlet
Cassidy Kessinger
Eliana Whitcomb
John M. Lee
Daniil P. Aksenov
Matthew Walker

Frontiers in Oncology

doi 10.3389/fonc.2026.1775053

Original Research

Published on 04 Mar 2026

Effects of weighted vests versus elastic bands plyometric jump training on lower-body physical performance adaptations in volleyball players

in Exercise Physiology

Yichen Bao
Yuankai Qiao
Shuowen Yang

Frontiers in Physiology

doi 10.3389/fphys.2026.1756391

Original Research

Published on 04 Mar 2026

The involvement of miRNAs in the enhanced immune response of oysters via haemocyte-mediated immune priming

in Comparative Immunology

Xiaoxu Zhou
Lixin Guo
Weilin Wang
Lingyuan Song
Yuefeng Dai
Jiajun Zuo
Lingling Wang
Linsheng Song

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753252

Original Research

Published on 04 Mar 2026

SIRT1 regulates glycolysis and angiogenesis of ovarian cancer through β-catenin/c-Myc/PKM2, and its mechanism in chemotherapy resistance

in Gynecological Oncology

Chengju Zhang
Hu Wang
Yu Zhou
Deng He
Tiantian Feng
Xi Wang
Shangqi Ni
Juan Zhang

Frontiers in Oncology

doi 10.3389/fonc.2026.1762850

Original Research

Published on 04 Mar 2026

Association of plasma ferritin and plasma iron at time of vaccination with the immune response to SARS-CoV-2 vaccination: a longitudinal cohort study

in Nutritional Immunology

Giulia Pestoni
Dominik Menges
Craig Fenwick
Pornpimol Scheuchzer
Julia Braun
Sarah R. Haile
Tala Ballouz
Christophe Zeder
Nicole U. Stoffel
Michael B. Zimmermann

Frontiers in Immunology

doi 10.3389/fimmu.2026.1764884

187 views

Articles

Antibody elution methods for multiplex immunofluorescence of Alzheimer's disease pathology in human post-mortem brain tissue

A real-world comparison study of the efficacy of dual-target first-line rescue treatment of human epidermal growth factor receptor 2 positive advanced breast cancer: trastuzumab combined with pertuzumab versus trastuzumab combined with pyrotinib

Predicting cardiovascular events in hemodialysis patients based on the fusion of physicochemical indicators and tongue images: a prospective and multicenter study

Total body water to lean body mass ratio predicts mortality in patients with chronic heart failure: a prospective, observational study

Dual-level weighted cross-entropy loss function and multi-object region segmentation network evaluation for dynamic knee joint X-ray radiography based on a novel scoring criterion

Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer after prior vascular endothelial growth factor receptor-targeted therapy (COSMIC-311): outcomes by BRAF status

Morphological changes and lateralization of the thalamic nuclei in children with growth hormone deficiency

Beyond body mass index: visceral adiposity and metabolic alterations as early markers of atrial dysfunction and atrial fibrillation in midlife

Variation of the steroid profile in relation to training in women and its importance for anti-doping testing

Comparison and excitation optimization of commercial quartz tuning forks for QEPAS

Astragalus small molecules protect BMSCs from radiation-induced bystander effect and enhance lung cancer radiosensitivity via the primary cilium/TGF-βR1/Smad3 pathway

Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma

Effects of weighted vests versus elastic bands plyometric jump training on lower-body physical performance adaptations in volleyball players

The involvement of miRNAs in the enhanced immune response of oysters via haemocyte-mediated immune priming

SIRT1 regulates glycolysis and angiogenesis of ovarian cancer through β-catenin/c-Myc/PKM2, and its mechanism in chemotherapy resistance

Association of plasma ferritin and plasma iron at time of vaccination with the immune response to SARS-CoV-2 vaccination: a longitudinal cohort study