Frontiers Article Alert

Wednesday, 15 April 2015

 

Frontiers is pleased to announce a number of exciting new articles in the field of Pharmacology.

 

Frontiers in Pharmacology, section “Cardiovascular and Smooth Muscle Pharmacology”

Ambiguities in dietary antioxidant supplementation compared to calcium channel blockers therapy
Théophile Godfraind and Salvatore Salomone

Frontiers in Pharmacology, section “Drug Metabolism and Transport”

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets
Marçal Pastor-Anglada and Sandra Pérez-Torras
The importance of iron in pathophysiologic conditions
Raffaella Gozzelino and Paolo Arosio
Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei
Jane Claire Munday, Luca Settimo, and Harry P de Koning
Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter
Darren Moss, Neill Liptrott, Marco Siccardi, and Andrew Owen

Frontiers in Pharmacology, section “Ethnopharmacology”

Clinical application of kampo medicine (rikkunshito) for common and/or intractable symptoms of the gastrointestinal tract
Kazunari Tominaga and Tetsuo Arakawa
Herbal medicines for the treatment of cancer chemotherapy-induced side effects
Shunsuke Ohnishi and Hiroshi Takeda
Citrus aurantium increases seizure latency to PTZ induced seizures in zebrafish thru NMDA and mGluR's I and II
Coral Rosa-Falero, Stephanie Torres-Rodríguez, Claudia Claudia Jordán, Rígel Licier, Yolimar Santiago, Zuleyma Toledo, Marely Santiago, Kiara Serrano, and José G. Ortiz
Hepatotoxic potential of asarones: in vitro evaluation of hepatotoxicity and quantitative determination in herbal products
Dhavalkumar Narendrabha Patel, Han Kiat Ho, Libei Liesbet Tan, Mui-Mui Belinda Tan, Qian Zhang, Min-Yong Low, Cheng-Leng Chan, and Hwee-Ling Koh
Application of morbid animal model in drug safety evaluation of traditional Chinese medicine
Ning Ke-Yong and Li Min
Citrus bergamia essential oil: from basic research to clinical application
Michele Navarra, Carmen Mannucci, Marisa Delbò, and Gioacchino Calapai
Constipation and herbal medicine
Norio Iizuka and Yoshihiko Hamamoto

Frontiers in Pharmacology, section “Experimental Pharmacology and Drug Discovery”

Absence of a significant pharmacokinetic interaction between atorvastatin and fenofibrate: a randomized, crossover, study of a fixed-dose formulation in healthy Mexican subjects
Omar Patiño-Rodríguez, Rosa María Martínez-Medina, Irma Torres-Roque, Maricela Martínez-Delgado, America Susana Mares-Garcia, Abraham Escobedo-Moratilla, Amador Covarrubias-Pinedo, Angélica Arzola-Paniagua, José Luis Herrera-Torres, and José Pérez-Urizar
Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors
Daniel Clayton, Iresha Hanchapola, Walter Glen Thomas, Robert Widdop, Alexander Ian Smith, Patrick Perlmutter, and Marie-Isabel Aguilar
Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive
Antoine Huart, Julie Klein, Julien Gonzalez, Bénedicte Buffin-Meyer, Eric Neau, Christine Delage, Denis Calise, David Ribes, Joost-Peter Schanstra, and Jean-Loup Bascands
Optimization of the cyclotide framework to improve cell penetration properties
Yen-Hua Huang, Stephanie Chaousis, Olivier Cheneval, David J. Craik, and Sonia Troeira Henriques
A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties
Hee-Kyoung Lee, Liuyin Zhang, Misty D Smith, Aleksandra Walewska, Nadeem Vellore, Riccardo Baron, J Michael McIntosh, H Steve White, Baldomero M Olivera, and Grzegorz Bulaj
Advantages and applications of CAR-expressing natural killer cells
Wolfgang Glienke, Ruth Esser, Christoph Priesner, Julia Suerth, Axel Schambach, Winfried Wels, Manuel Grez, Stephan Kloess, Lubomir Arseniev, and Ulrike Koehl
G-protein coupled receptors of the renin-angiotensin system: new targets against breast cancer?
Clara NAHMIAS and Sylvie RODRIGUES-FERREIRA
Defining the microbial effluxome in the content of the host-microbiome interaction
Anastasios Ioannidis, Maria Magana, Cristian Bologa, Tudor Oprea, Ian Paulsen, and George Tegos
Systems pharmacology approaches for optimization of antiangiogenic therapies: challenges and opportunities
Satish Sharan and Sukyung Woo
The relevance of theobromine for the beneficial effects of cocoa consumption
Eva Martínez-Pinilla, Ainhoa Oñatibia-Astibia, and Rafael Franco
HIV drug nucleoside reverse transcriptase inhibitors as promising anti-inflammation therapeutics by targeting P2X7-dependent large pore formation: one stone for two birds?
Lin-Hua Jiang
Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation
Nathanne Santos Ferreira, Stêfany Bruno Assis Cau, Marcondes Alves Barbosa Silva, Carla Pavan Manzato, Fabíola Leslie Antunes Cardoso Mestriner, Takayuki Matsumoto, Fernando Silva Carneiro, and Rita Cassia Tostes
Identification of agonists for a group of human odorant receptors
Daniela Gonzalez-Kristeller, João Batista Plácido do Nascimento, Pedro A F Galante, and Bettina Malnic
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors
Sabrina M de Munnik, Martine J Smit, Rob Leurs, and Henry F Vischer
Potential role of glutathione in evolution of thiol-based redox signaling sites in proteins
Kaavya A Mohanasundaram, Naomi L Haworth, Mani P Grover, Tamsyn M Crowley, Andrzej Goscinski, and Merridee Ann Wouters
Physiological implications of biased signaling at histamine H2 receptors
Natalia Alonso, Carlos Daniel Zappia, Maia Cabrera, Carlos Alberto Davio, Carina Shayo, Federico Monczor, and Natalia Cristina Fernandez
(–)–Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice
Icksoo Lee, Maik Hüttemann, Adele Kruger, Aliccia Bollig-Fischer, and Moh H. Malek
Peptide ligand recognition by G protein-coupled receptors
Brian E Krumm and Reinhard Grisshammer
Progress in antiandrogen design targeting hormone binding pocket to circumvent mutation based resistance
Xiaohong Tian, Yang He, and Jinming Zhou
New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway.
Rosely Oliveira Godinho, Thiago Duarte, and Enio Setsuo Arakaki Pacini
A pretargeting system for tumor PET imaging and radioimmunotherapy
Françoise Kraeber-Bodéré, Caroline Rousseau, Caroline Bodet-milin, Eric Frampas, Alain Faivre-Chauvet, Aurore Rauscher, Robert Sharkey, David Goldenberg, Jean-Francois Chatal, and Jacques Barbet
Large-scale production and protein engineering of G protein-coupled receptors for structural studies
Dalibor Milić and Dmitry B. Veprintsev
Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood
Kely de Picoli Souza, Elton Dias da Silva, Elice Carneiro Batista, Felipe Castellani Gomes Reis, Sylvia Maria Affonso Silva, Charlles H. M. Castro, Jaqueline Luz, Jorge Luiz Pesquero, Edson Lucas dos Santos, and Joao Bosco Pesquero

Frontiers in Pharmacology, section “Inflammation Pharmacology”

Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer
Tina Horbach, Claudia Götz, Thomas Kietzmann, and Elitsa Y Dimova

Frontiers in Pharmacology, section “Inflammation Pharmacology” (Continued)

Herbal medicine IMOD suppresses LPS-induced production of proinflammatory cytokines in human dendritic cells
Saeedeh Mirzae, Agata Drewniak, Ramin Sarrami-Forooshani, Tanja M Kaptein, Farhad Gharibdoost, and Teunis B. Geijtenbeek
Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue
Ivana Zagotta, Elitsa Y. Dimova, Klaus-Michael Debatin, Martin Wabitsch, Thomas Kietzmann, and Pamela Fischer-Posovszky

Frontiers in Pharmacology, section “Integrative and Regenerative Pharmacology”

Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells
Hong Zhan Wang, Barbara Rosati, Chris Gordon, Virginijus Valiunas, David McKinnon, Ira S Cohen, and Peter R Brink
Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy
Tippi C. Mackenzie
NK cell tolerance as the final endorsement of prenatal tolerance after in utero hematopoietic cellular transplantation
Amir Alhajjat, Amanda Lee, Beverly Strong, and Aimen Shaaban
Engineering muscle tissue for the fetus: getting ready for a strong life
George Joseph Christ, Mevan Siriwardane, and Paolo De Coppi

Frontiers in Pharmacology, section “Neuropharmacology”

Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Katia Befort
Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport
William C. Griffin, Vorani S. Ramachandra, Lori A Knackstedt, and Howard C Becker
Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing N-methyl-D-aspartate receptors in the nucleus accumbens
Natalie S McGuier, Audrey E Padula, Patrick J Mulholland, and Lawrence Judson Chandler
Utilizing GCaMP transgenic mice to monitor endogenous Gq/11-coupled receptors
John G Partridge
Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking
Ana Weiland, Steven Garcia, and Lori A Knackstedt
Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?
Bruno Pierre Guiard and Giuseppe Di Giovanni
IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala
Michal Bajo, Florence P Varodayan, Samuel G Madamba, Amanda J Roberts, Lindsey M Casal, Christopher Oleata, George Robert Siggins, and Marisa Roberto

Frontiers in Pharmacology, section “Obstetric and Pediatric Pharmacology”

Drug therapy for the prevention and treatment of bronchopulmonary dysplasia
Anjali Iyengar and Jonathan Michael Davis
Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn
Stephen Wedgwood, Satyan Lakshminrusimha, Paul T Schumacker, and Robin Steinhorn

Frontiers in Pharmacology, section “Pharmaceutical Medicine and Outcomes Research”

Do interprofessional education programs produce dissension that destroys them?
Lon J Van Winkle
Early steps in inner ear development: induction and morphogenesis of the otic placode
Xaiorei Sai and Raj K. Ladher
Circadian clock disruption in neurodegenerative diseases: cause and effect?
Erik Steven Musiek
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease
Nina Divorty, Amanda E Mackenzie, Stuart A. Nicklin, and Graeme Milligan
Rodent models to study the metabolic effects of shiftwork in humans
Anne-Loes Opperhuizen, Linda WM van Kerkhof, Karin I Proper, Wendy Rodenburg, and Andries Kalsbeek
Effect of ultra violet irradiation on the interplay between Th1 and Th2 lymphocytes
Salma Y Abo Elnazar, Amany Abd-Elkader Ghazy, Hossam E. Ghoneim, AbdulRahman M. Taha, and Amira M Abouelella
7a, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases
Siquan Sun and Changlu Liu
The histamine H4 receptor: from orphan to the clinic
Robin L. Thurmond
Recent advances in circadian rhythms in cardiovascular system
Lihong Chen and Guangrui Yang
Effect of murine exposure to gamma rays on the interplay between Th1 and Th2 lymphocytes
Amany Abd-Elkader Ghazy, Salma Y. Abo-Elnazar, Hossam E. Ghoneim, Abdul-Rahman M. Taha, and Amira M. Abouelella
Cost-effectiveness of prucalopride in the treatment of chronic constipation in the Netherlands
Mark J C Nuijten, Dominique J Dubois, MD, Alain Joseph, and Lieven Annemans
Education and training for medicines development, regulation, and clinical research in emerging countries
Sandor - Kerpel-Fronius, Bernd Rosenkranz, Elizabeth Allen, Rolf Bass, Jacques Demotes Mainard, Alex Dodoo, Dominique J Dubois, Mandisa Hela, Steven Kern, JOAO MASSUD, Honorio Silva, and Jeremy Whitty

Frontiers in Pharmacology, section “Pharmacogenetics and Pharmacogenomics”

Genetic determinants for methotrexate response in juvenile idiopathic arthritis
Serena Pastore, Gabriele Stocco, Diego Favretto, Sara De Iudicibus, Andrea Taddio, Pio d'Adamo, Riccardo Addobbati, Giuliana Decorti, Loredana Lepore, and Alessandro Ventura
Whole genome sequencing in pharmacogenomics
George P Patrinos and Theodora Katsila

Frontiers in Pharmacology, section “Pharmacology of Anti-Cancer Drugs”

The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies
Hae Jung Chon, Kyoung Jun Bae, Yura Lee, and Jiyeon Kim

Frontiers in Pharmacology, section “Pharmacology of Ion Channels and Channelopathies”

Dynamics of receptor-operated Ca2+ currents through TRPC channels controlled via the PI(4,5)P2-PLC signaling pathway
Masayuki X Mori, Kyohei Itsuki, Hideharu Hase, Seishirou Sawamura, Tatsuki Kurokawa, Yasuo Mori, and Ryuji Inoue
A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases
Angeliki Mavrantoni, Veronika Thallmair, Michael G Leitner, Daniela N Schreiber, Dominik Oliver, and Christian R Halaszovich
Voltage-sensing phosphatase modulation by a C2 domain
Paul M. Castle, Kevin D. Zolman, and Susy C. Kohout

Frontiers in Pharmacology, section “Predictive Toxicology”

M2 polarization enhances silica nanoparticle uptake by macrophages
Jessica Hoppstädter, Michelle Seif, Anna Dembek, Christian Cavelius, Hanno Huwer, Annette Kraegeloh, and Alexandra K Kiemer
A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
Hitesh Mistry, Mark Richard Davies, and Giovanni Y Di Veroli
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