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Front. Mol. Neurosci. | doi: 10.3389/fnmol.2019.00208

Phosphoinositides: regulators of nervous system function in health and disease

 Padinjat Raghu1*,  Annu Joseph1, Harini Krishnan1, Pramod Singh1 and Sankhanil Saha2
  • 1National Centre for Biological Sciences, India
  • 2National Centre for Biological Sciences, India

Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have emerged as key regulators of multiple sub-cellular processes such as membrane transport, cytoskeletal function and signalling in eukaryotic cells. All of these processes are also present in the cells that constitute the nervous system of animals and in this setting too phosphoinositides are likely to regulate key aspects of cell biology tuned to the unique aspects of cell biology of neurons. Phosphoinositides metabolism and function are mediated by enzymes and proteins that are conserved in evolution and analysis of knockouts of these in animal models implicate this signalling system in neural function. Most recently, with the advent of human genome analysis, mutations that impact components of the phosphoinositide signalling pathway has been implicated in human diseases although the cell biological basis of disease in many cases remains unclear. In this review we evaluate existing evidence for the involvement of phosphoinositide signalling in human nervous system diseases and discuss ways of enhancing our understanding of the role of this pathway in human nervous system function in health and disease.

Keywords: phosphoinositides, brain disease, Genetics, Cellular organelles*, Inherited disorders, human genetics and genomics, neurologcial disorders

Received: 23 Mar 2019; Accepted: 07 Aug 2019.

Copyright: © 2019 Raghu, Joseph, Krishnan, Singh and Saha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Padinjat Raghu, National Centre for Biological Sciences, BANGALORE, India,