Research Topic

Immune Response to Cerebral Ischemia: Exploring Mechanisms and Potential Treatment Targets

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Stroke is a leading cause of death and adult disability worldwide, and around 80% are ischemic strokes. Over the past decades, despite the great progress in understanding stroke pathophysiology and the tremendous efforts in developing drugs with brain-protective effects, tissue plasminogen activator (tPA) is ...

Stroke is a leading cause of death and adult disability worldwide, and around 80% are ischemic strokes. Over the past decades, despite the great progress in understanding stroke pathophysiology and the tremendous efforts in developing drugs with brain-protective effects, tissue plasminogen activator (tPA) is still the only acute pharmacological treatment ischemic stroke approved by the FDA.

In the past decades, extensive clinical findings and numerous studies in experimental animal models delineated the critical roles of the immune system in acute neuronal tissue damage development and long-term recovery following ischemic stroke. These studies also raised the hopes in treatment of stroke by modulating immunity. However, whether these post-stroke immune responses are beneficial or detrimental to tissue damage is still under debate. In this case, a better understanding of the roles of immune response, as well as the mechanisms of how immune cell and mediators are involved in stroke-induced neuroinflammation will pave the way for developing new immunomodulatory therapies and novel treatments for ischemic stroke.

This Research Topic will provide a comprehensive overview on the molecular mechanisms underlying the immune response following ischemic stroke and novel therapeutic strategies for recovery after cerebral ischemia . In particular, this collection of articles will focus on immune cells and mediators involved in ischemic brain injury and recovery, such as macroglia, myeloid and lymphoid cells, cytokines, damaged associated molecular patterns (DAMPs), hypothalamic-pituitary-adrenal (HPA) axis, as well as other immune or inflammatory events and signaling pathways. We welcome the submission of Original Research articles and Reviews covering, but not limited to, the following topics:

1. The cellular and molecular mechanisms underlying the innate and adaptive immune response induced by cerebral ischemia.
2. Stroke-induced immunodepression and post-stroke infection after cerebral ischemia.
3. The application of novel technologies in studying post-stroke immune response, such as single-cell RNA analysis, Cytometry by time-of-flight, whole-genome transcriptomic and proteomic analysis.


Keywords: Cerebral ischemia, Immune system, Inflammation, Immunodepression, Cytokines


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