Research Topic

Advances in Diagnosis and Treatment of TBI-Induced Neurodegeneration and Cognitive Deficits

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About this Research Topic

Many people worldwide suffer from traumatic brain injury (TBI) each year due to traffic, personal or sports accidents, and criminal or war activities. To date, no effective therapies are available, due to our incomplete understanding of the evolving nature of TBI neuropathology. For example, patients with a ...

Many people worldwide suffer from traumatic brain injury (TBI) each year due to traffic, personal or sports accidents, and criminal or war activities. To date, no effective therapies are available, due to our incomplete understanding of the evolving nature of TBI neuropathology. For example, patients with a “normal” neuroimage and clinical diagnosis following TBI may abruptly pass away days or months later.

A significant portion of TBI patients also suffer from the co-morbidities: neurodegenerative disorders and post-traumatic stress disorder (PTSD). Recent studies suggest that TBI-induced oxidative stress can cause accelerated aging and neurodegeneration. Advances have also been made in diagnosis and treatment of TBI over the last several years, which has created high hope for the development of more effective therapies. At the recent symposiums on TBI, held at NIH, many studies examined the most critical factors and technologies for diagnosis and treatment of TBI and PTSD.

The aims of this Research Topic are to investigate advances in diagnosis and treatment of TBI-induced neurodegeneration and cognitive deficits. Potential studies should include but are not limited to the following:

· evaluation of technologies and tools for monitoring, assessing and predicting the severity of structural and functional brain damage, long-term outcome of TBI, and associated stress, vascular pathology, axon-myelin pathology, axon degeneration, including bioinformatics and machine learning;
· studies of oxidative stress, redox homeostasis, neuroinflammation, astrocyte/macrophage/microglia activation, neuroimmune-endocrine interaction, Abeta, Tau, GFAP and Iba-1 that could predict TBI-induced functional and cognitive decline, accelerated aging and neurodegeneration;
· therapeutic studies including pharmacological and non-pharmacological interventions, rTMS, recreation & art therapy, dietary and herbal medicine, and cognitive-behavior therapy;
· study of psychological factors that precipitates the detrimental effects of TBI;
· review articles that describe the current state of the art in TBI research.

We encourage researchers and clinicians to contribute to this Research Topic with emphasis on TBI-induced Neurodegeneration and cognitive deficit, and the following article types: Original Research, Brief Research Report, Case Report, Clinical Trial, Study Protocol, Hypothesis and Theory, Methods, Mini Review, Opinion, Perspective, Review, Meta-analysis and Systematic Review.


Keywords: Oxidative Stress, Neurodegeneration, TBI, Diagnosis & Treatment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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