About this Research Topic
During brain development, neuropeptides modulate neuron precursor proliferation, migration, differentiation and/or survival. In peripheral tissues, bioactive peptides orchestrate Sertoli cell multiplication in the testis, myocyte growth in the heart and enterocyte number in the intestine. At adulthood, neuropeptides control proliferation of neural stem cells and induce mobilization of bone marrow stem cells.
In pathophysiological conditions, certain neuropeptides are involved in Alzheimer's disease (AD) or exacerbate the deleterious effects of stroke, while others protect cell death in AD, Parkinson's disease and stroke models. Besides, bioactive peptides can stimulate ovarian cancer cell proliferation or decrease prostatic tumor growth. When the trophic effect is exerted by a protein, peptide agonists or antagonists can be designed to mimic or suppress the biological response.
These few examples, far from covering the entire field, illustrate the pleiotropic functions of peptides and their immense potential for the development of tomorrow's medicines.
The scope of this Research Topic is to highlight the involvement of peptides in the control of cell survival, proliferation and plasticity in physiological and pathological settings. Recognized experts of the different peptides in this field will be invited to write authoritative and comprehensive review articles (at least 15 review papers, each on a different peptide). In addition, we will welcome spontaneous submissions of original research manuscripts on either preclinical or translational studies.
Keywords: Peptides, cell plasticity, neuroprotection, tumor growth, organ development
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