Research Topic

Interplay Between Ion Channels, the Nervous System, and Embryonic Development

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Ion channels play fundamental second-to-second roles in maintaining appropriate ion gradients and membrane potentials for all cells and rapid signaling in excitable cells. More recent work has revealed that ion channels play critical roles in the development of excitable and non-excitable cells, neural ...

Ion channels play fundamental second-to-second roles in maintaining appropriate ion gradients and membrane potentials for all cells and rapid signaling in excitable cells. More recent work has revealed that ion channels play critical roles in the development of excitable and non-excitable cells, neural degeneration, disease, and tissue remodeling/cellular regeneration. Examples of ion channels with associated channelopathies that have revealed such novel roles include Kv3.1,Kir2.1, Kir7.1 and GIRK2.

Elucidation of these non-conventional roles of ion channels will provide an understanding into novel mechanisms that underlie the development, degeneration and/or regeneration of excitable and non-excitable cells. Moreover, as ion channels serve as potential drug targets, elucidation of their non-traditional roles will allow for innovative new therapeutic approaches.

This Research Topic focuses on non-conventional roles played by ion channels in development, disease, and repair of excitable and non-excitable tissues. All types of manuscripts, ranging from research papers to focused reviews, are welcome.


Keywords: ion channels, electrical signaling, ion gradients, ion fluxes, model organisms


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