Research Topic

Image-guided Neurointerventions for Targeting Therapeutic Agents to the Brain

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About this Research Topic

Endovascular Neurointerventions have revolutionized treatment of central nervous system (CNS) disorders, as exemplified by the breakthrough of thrombectomy for large vessel stroke. MRI-guided Convection-enhanced delivery (CED) improves precision and efficacy of treatments for various diseases from Parkinson’s ...

Endovascular Neurointerventions have revolutionized treatment of central nervous system (CNS) disorders, as exemplified by the breakthrough of thrombectomy for large vessel stroke. MRI-guided Convection-enhanced delivery (CED) improves precision and efficacy of treatments for various diseases from Parkinson’s disease to brain tumors. These techniques offer the perspective to deliver therapeutics with unprecedented precision wherever and whenever needed. With new generations of interventional devices, advances in imaging and therapeutics tailored for individual route of delivery, these create opportunities for novel, precise and personalized treatments. However, these targeted delivery approaches have just emerged as a new field of translational neuroscience, with many basic and application-related questions yet unresolved.

This Research Topic will address these questions by focusing on the unmet need for effective delivery of therapeutic agents to the brain. It will emphasize the value of advanced imaging to guide neurointerventions and to monitor drug pharmacokinetics from the moment of delivery through initial biodistribution and subsequent clearance from the CNS. This Topic also aims to review current neurointerventions with their particular strengths and weaknesses. Finally, it will put a spotlight on the novel techniques and interventional possibilities that will emerge within the next years.

Topics include:
A. Intra-arterial approaches for treatment of stroke, neoplasms and other neurological disorders;
B. Old dog, new tricks: ultrasound for neurointerventional strategies;
C. Biomaterials and Nanotechnologies in neurointervetions;
D. Animal modelling for advanced neurointerventions.


Keywords: Neurointervention, Imaging-Guided, Neurooncology, Drug and Cell Delivery, Blood Brain Barrier, Translational Research


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