About this Research Topic
In the framework of this Research Topic, submission of both Original Research manuscripts and Reviews/Mini-Reviews/Perspective/Opinion articles will be encouraged on any relevant subjects dealing with the immune regulation of metabolic homeostasis in health and diseases, including but not restricted to the following themes:
· Characterization and role of various immune cell populations in organ-specific regulation of metabolic functions and/or systemic meta-inflammation and metabolic homeostasis
· Contribution of gut microbiota and/or central nervous system to the regulation of peripheral immune response and metabolic homeostasis during obesity, type 2 diabetes and cardiovascular diseases
· Role of tissue microenvironment (nutrients, metabolites, oxygen,…) and/or any cellular signaling in the regulation of immune cell metabolism and functions in metabolic organs
· Methods/strategies for manipulating the immune system to alleviate meta-inflammation and/or restore cardiometabolic homeostasis (e.g. immune cell-specific targeted drug delivery, use of biomaterials, immunomodulation with parasite molecules or dietary intervention with probiotics…)
· Link between obesity/type 2 diabetes, dysregulated innate immune responses and increased risk for both bacterial and viral infections
· Epidemiological studies focusing on the relationships between altered immune responses and incidence/prevalence of obesity, NAFLD, NASH, type 2 diabetes and/or cardiovascular diseases in various environmental contexts and populations
· Clinical trials investigating novel approaches for the prevention and treatment of hyper-inflammatory cardiometabolic diseases
- Links with bone metabolism
Keywords: Obesity, Meta-inflammation, Immunometabolism, Immune cells, Insulin resistance, Diabetes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.