About this Research Topic
The regulation of phagocytes in non-mammals are also diverse. Phagocytes in mammals consist mainly of macrophages and neutrophils, while in teleosts B lymphocytes and thrombocytes from peripheral blood also have potent phagocytic activity. Teleost-specific genome duplication events produce genes with overlapping functions, potentially resulting in sub-functionalization in the teleost immune system. An example of this is CXCR3.1 and CXCR3.2 in teleosts, which differentially contribute to macrophage polarization. In invertebrates, such as drosophila, mosquito, cuttlefish and shrimp, hemocytes display phagocytic activities. Although invertebrates lack acquired immunity, the down syndrome cell adhesion molecule (DSCAM) is thought to provide a somatically diversified receptor system to enable challenge-specific protection in insects, in addition to enhancing the phagocytic capability of hemocytes.
In this Research Topic, we aim to clarify and review the regulation of phagocytes in non-mammals. Investigating the regulation of phagocytes in non-mammalian systems provides a unique opportunity to improve our understanding of the mechanisms that help regulate immunity generally, and in turn improve our treatment of infectious diseases in both animals and humans. We welcome the submission of original research and review articles that include, but are not limited to, the following topics:
1. Phagocyte development, differentiation, migration and apoptosis.
2. Anti-microorganism functions of phagocytes.
3. Phagocytes in tissue development, homeostasis and repair.
4. Phagocyte activation and polarization.
5. Phagocyte role in disease processes.
6. Orchestration of metabolism in phagocytes.
7. Evolutionary and comparative perspectives of phagocytes.
8. Phagocyte regulation by soluble proteins such as cytokines.
9. Receptor activation and regulation of phagocytes.
10. Intracellular signaling pathways of phagocytes.
Keywords: Phagocytes, Macrophages, Neutrophils, B lymphocytes, Hemocytes
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