About this Research Topic
In this scenario, public concern about potentially harmful health effects of BPA has led to its removal from many plastic products, particularly related to babies and infants. In its place, structurally similar compounds are being employed, such as bisphenol B (BPB), bisphenol F (BPF) and bisphenol S (BPS). The BPA substitutes-based products are marketed under the label of “BPA-free”, giving the impression of safety, which, however, has not yet been fully verified. Indeed, due to structural similarities with BPA, also these alternatives could exert endocrine disruption activities and some studies on their possible adverse effects on health outcomes, including reproduction, are being reported. In particular, in rodents, the neuroendocrine disruptive effects of BPA analogues lead to behavioral changes and affect testosterone levels, spermatogenesis and sperm DNA integrity.
The objective of this Research Topic is group a collection of original articles, meta-analyses, reviews, or mini-reviews focused on new and more recent insights about the impact of bisphenols on male reproductive health, involving experts from different areas of medicine (endocrinology, andrology, genetic, etc.). We suggest the submission of abstracts with the following proposals: pathophysiology of the possible reproductive toxicity of BPA and its analogues in in vitro and in vivo models, possible reproductive reflections of epigenetic effects of bisphenols, critical reviews on facts and myths regarding the still controversial impact of bisphenols on human reproduction.
We suggest the submission of manuscripts with the following themes (but not limited to):
-pathophysiology of the reproductive toxicity of BPA and its analogues in in vitro and in vivo models
-possible reproductive reflections of epigenetic effects of bisphenols
-prevention and protection strategies.
Keywords: Bisphenol, Endocrine disruptors, Male fertility, Spermatozoa, Testis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.