About this Research Topic
Current health research must understand the fine-tuned communication between the many, seemingly distinct systems in the body. Previous studies have established the routes by which the immune and central nervous (CNS) systems interact.
This network of connections permits the CNS to regulate the immune system and vice versa. It is now well established that in several neurological disorders there is an imbalance or aberrant communication between both systems.
For several years, the study of such communications has linked the brain with signals originated from accessory immune cells such as monocytes and macrophages. However, several lines of evidences indicate that an important crosstalk between astrocytes and microglia is critical to keep homeostatic conditions and might compromise neuronal and oligodendroglial viability under pathological conditions.
The present Research Topic suggests to deepen the current knowledge on these interactions and to explore the novel and state-of-the-art therapeutic strategies that take advantage of the brain-immune cross-talk in the treatment of neurological diseases.
This Research Topic encourages the participation of well-established research groups that work in this field, to submit research and/or opinion and/or review manuscripts that fit with the following sub-topics:
-Synaptic modulation by the immune system and the main innate immune cells of the central nervous system (CNS) in neurodegenerative/neuropsychiatric disorders.
-Influence of astrocytes on microglia behavior and its consequences on neuron and oligodendrocyte viability/function as well as disease outcome.
-Influence of microglia on astrocytes reactivity and its consequences on neuron and oligodendrocyte viability/function as well as disease outcome.
-Invasion of immune cells in the brain and pathological/functional modulation of neural cells associated.
- Modulation of peripheral immune system and innate immune cells of the brain (astrocytes and microglia) to treat neurodegenerative/neuropsychiatric disease
Neurodegenerative diseases could include Alzheimer's disease or Parkinson's disease or Huntington's disease among others.
Keywords: Microglia, Immune Cells, Synaptic Engulfment, Cell Invasion, Therapy, Neuroinflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.