In recent years, intriguing findings of immunological and central nervous system (CNS) close interactions has challenged the conventional wisdom of CNS immune privilege. Diverse immune mechanisms on what has been called “the inflamed brain” have been associated with the pathophysiology of a wide spectrum of neuropsychiatric (NP) diseases. Indeed, chronic inflammation and autoimmune diseases may induce different NP disorders in susceptible patients. Schizophrenia is an archetypal neurodevelopmental disease associated with early-life immunological insults and inflammation. Conversely, NP diseases may be linked to primary immunodeficiencies (for instance, schizophrenia and velocardiofacial syndrome or DiGeorge syndrome). Moreover, NP and their therapies may induce secondary immunosuppression, which may have relevant clinical and prognostic implications for these patients. Evidence suggests that common mediators playing a role in schizophrenia onsets, such as proinflammatory cytokines and specific neurotransmitters are shared by immune and neural cells and may point to altered gut microbiota.
The Crossroads between Immunological Disorders and Neuropsychiatric Diseases is the theme of focus of this Research Topic. Our aim is to gather together a series of original research articles, clinical trials, mini-reviews, reviews and perspectives covering the breadth of neuroimmune research, but not limited to, the following topics:
1.- Emerging link of the immunological alterations and neuropsychiatric diseases pathophysiology and the biological mechanisms involved in it.
2.- New findings on neuropsychiatric diseases associated with primary and secondary immune disorders.
3.- Mechanisms involved in the gut-immune system-brain axis.
4.- Technological progress for addressing the immune-brain crossroads.
5.- Immunomodulatory effects of antipsychotic treatments.
6.- Neuromodulatory effects of anti-inflammatory treatments.
3.- Strategies for advancing in the integrative insight of psychoneuroimmune metasystem
In recent years, intriguing findings of immunological and central nervous system (CNS) close interactions has challenged the conventional wisdom of CNS immune privilege. Diverse immune mechanisms on what has been called “the inflamed brain” have been associated with the pathophysiology of a wide spectrum of neuropsychiatric (NP) diseases. Indeed, chronic inflammation and autoimmune diseases may induce different NP disorders in susceptible patients. Schizophrenia is an archetypal neurodevelopmental disease associated with early-life immunological insults and inflammation. Conversely, NP diseases may be linked to primary immunodeficiencies (for instance, schizophrenia and velocardiofacial syndrome or DiGeorge syndrome). Moreover, NP and their therapies may induce secondary immunosuppression, which may have relevant clinical and prognostic implications for these patients. Evidence suggests that common mediators playing a role in schizophrenia onsets, such as proinflammatory cytokines and specific neurotransmitters are shared by immune and neural cells and may point to altered gut microbiota.
The Crossroads between Immunological Disorders and Neuropsychiatric Diseases is the theme of focus of this Research Topic. Our aim is to gather together a series of original research articles, clinical trials, mini-reviews, reviews and perspectives covering the breadth of neuroimmune research, but not limited to, the following topics:
1.- Emerging link of the immunological alterations and neuropsychiatric diseases pathophysiology and the biological mechanisms involved in it.
2.- New findings on neuropsychiatric diseases associated with primary and secondary immune disorders.
3.- Mechanisms involved in the gut-immune system-brain axis.
4.- Technological progress for addressing the immune-brain crossroads.
5.- Immunomodulatory effects of antipsychotic treatments.
6.- Neuromodulatory effects of anti-inflammatory treatments.
3.- Strategies for advancing in the integrative insight of psychoneuroimmune metasystem