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Polygenic Risk Scores

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Polygenic risk scores (PRS) have gained prominence as a genetic tool with the promise to revolutionize medicine and improve biomedical outcomes at the level of individuals. However, the clinical utility of PRS will certainly vary between diseases and populations of different ancestries. To realize the full ...

Polygenic risk scores (PRS) have gained prominence as a genetic tool with the promise to revolutionize medicine and improve biomedical outcomes at the level of individuals. However, the clinical utility of PRS will certainly vary between diseases and populations of different ancestries. To realize the full and equitable potential of PRS, we are calling for papers that evaluate PRS for traits and diseases in diverse populations and also works that address potential ethical and scientific challenges surrounding the clinical implementation of PRS.


Keywords: genetic risk scores, single nucleotide polymorphism, SNP, genome-wide association, association


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