About this Research Topic
Although the renin-angiotensin system (RAS) is traditionally regarded as a system that controls hydroelectrolyte balance and blood pressure, a range of evidence points to the role of this system in different cerebral functions such as motor control and emotion. All RAS components can be found in the central nervous system (CNS) and it is currently assumed that there is a local brain RAS. Therefore, some studies have investigated the role played by the RAS in CNS disorders including stroke, Alzheimer's disease, and Parkinson’s disease. The RAS plays a major role in oxidative stress and inflammatory processes control, being a potential link between oxidative stress / inflammation and neuronal degeneration in CNS diseases.
This Research Topic will cover promising, recent, and novel research trends on the role played by the RAS in the CNS and in CNS-related diseases.
Areas of interest to be covered in this Research Topic include:
• The role of RAS on neurotransmitters release;
• The role played by RAS on oxidative stress and inflammatory responses;
• Pharmacological manipulation of the RAS as a potential therapy for neuropsychiatric disorders;
• Epidemiological studies investigating the association between RAS-modulators and risk and / or serevity of CNS diseases;
• RAS components as biomarkers of CNS diseases.
Keywords: Renin-angiotensin system, angiotensin, angiotensin-converting enzyme, brain, neuropsychiatry
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