Research Topic

Genome Engineering and Gene Editing in Neuronal and Glial Cells

About this Research Topic

Genomic editing is going to transform the scientific landscape by accelerating key developments in many disciplines. Although several gene editing approaches with strong clinical impact have been implemented, only a minority of them have direct application to the central nervous system. These limitations are ...

Genomic editing is going to transform the scientific landscape by accelerating key developments in many disciplines. Although several gene editing approaches with strong clinical impact have been implemented, only a minority of them have direct application to the central nervous system. These limitations are principally due to the intrinsic hurdles in the delivery of the gene editing tools across the brain as well as the limitations in modifying the neuronal genome. Since neurons are post-mitotic cells their genome is reluctant to targeted DNA modifications mediated by the homology-directed-repair (HDR) mechanism. However, innovative methods and approaches have been shown to have the ability to modify (e.g. HITI) or manipulate the expression (e.g. CRISPRa/i) of neuronal genes for potentially treating neurological diseases.

The aim of this Research Topic (research articles and reviews) is to explore recent advances in gene editing applications in neural cells, focusing on the development and/or application of new tools to modify neural cells in vitro and in vivo, from proof-of-concept studies to potential therapeutic approaches.


Keywords: gene editing, neurological diseases, genome engineering, neuronal and glial cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..