Research Topic

Involvement of Blood Brain Barrier Efficacy, Neurovascular Coupling and Angiogenesis in the Healthy and Diseased Brain

About this Research Topic

The brain is one of the most perfused organs in the body and the vascular network irrigating it is highly specialized. Firstly, the blood brain barrier is a unique, specific, and highly-organized system designed to regulated exchanges between blood and brain. It also protects the brain against xenobiotic agents and toxic metabolites produced in answer to aggression from the environment. Moreover, the arteriolar and capillary network is a highly reactive system that regulates cerebral blood flow and volume dynamically. The network controls brain perfusion and oxygenation needed by the neuronal network to produce cognition and behaviors. This neurovascular coupling, the mechanism sustaining the brain functional hyperemia, is able to drive a rapid and localized modulation of brain perfusion induced by neuronal activity. This last function is the basis of functional brain imaging techniques, such as fMRI and the new fast ultrasound imaging (fUS), usable with freely-moving animal models. Finally, the angiogenic factors are also known as regulators of neuronal proliferation, differentiation, and nerve guidance. These factors will be released during physiological and pathological vascular reprogramming processes.

This Research Topic would be attractive for publication of studies regarding blood brain barrier function, neurovascular coupling and links between vascular pathologies, and neurodegenerative disorders and psychopathologies. The studies focused on cell interactions (endothelial cells, pericytes, astrocytes and neurons), vascular reactivity and specificity of pial and penetrating arteries, the reprogramming of vascular cells and networks after traumatic brain injury and regulation of blood brain barrier are encouraged. Pathological aspects as implication of blood brain barrier and arterial dysfunctions that may lead to neurodegenerative disorders are also considered. Finally, new concepts and new technics that are also relevant to participate to the elucidation of vascular network are welcomed.


Keywords: blood brain barrier, cerebral artery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The brain is one of the most perfused organs in the body and the vascular network irrigating it is highly specialized. Firstly, the blood brain barrier is a unique, specific, and highly-organized system designed to regulated exchanges between blood and brain. It also protects the brain against xenobiotic agents and toxic metabolites produced in answer to aggression from the environment. Moreover, the arteriolar and capillary network is a highly reactive system that regulates cerebral blood flow and volume dynamically. The network controls brain perfusion and oxygenation needed by the neuronal network to produce cognition and behaviors. This neurovascular coupling, the mechanism sustaining the brain functional hyperemia, is able to drive a rapid and localized modulation of brain perfusion induced by neuronal activity. This last function is the basis of functional brain imaging techniques, such as fMRI and the new fast ultrasound imaging (fUS), usable with freely-moving animal models. Finally, the angiogenic factors are also known as regulators of neuronal proliferation, differentiation, and nerve guidance. These factors will be released during physiological and pathological vascular reprogramming processes.

This Research Topic would be attractive for publication of studies regarding blood brain barrier function, neurovascular coupling and links between vascular pathologies, and neurodegenerative disorders and psychopathologies. The studies focused on cell interactions (endothelial cells, pericytes, astrocytes and neurons), vascular reactivity and specificity of pial and penetrating arteries, the reprogramming of vascular cells and networks after traumatic brain injury and regulation of blood brain barrier are encouraged. Pathological aspects as implication of blood brain barrier and arterial dysfunctions that may lead to neurodegenerative disorders are also considered. Finally, new concepts and new technics that are also relevant to participate to the elucidation of vascular network are welcomed.


Keywords: blood brain barrier, cerebral artery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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