Research Topic

The Expanding Spectrum of Infectious and Immune-Mediated Etiologies of Acute Encephalitis: Challenges and Approaches to Diagnosis and Management

About this Research Topic

Neurologists’ knowledge of the expanding spectrum of infectious and immune-mediated encephalitides is a growing necessity in clinical practice. The impact of increasing globalization and expansion into previously undeveloped areas has led to the emergence of several viruses with a predilection for central nervous system (CNS) involvement. In parallel, the expansion of our knowledge of immune-mediated causes of encephalitis has led to growing complexity in defining the underlying causes of brain inflammation. With the expanded use of immunomodulators in various disease processes and immunotherapy in cancers, we are identifying a growing spectrum of previously unrecognized immune-mediated causes of CNS inflammation.

Despite recent advances in diagnostic and therapeutic modalities for infectious and autoimmune encephalitis, the management of patients with suspected or confirmed encephalitis poses a great challenge to physicians. In this Research Topic we aim to provide novel scientific data around laboratory testing for infectious and immune-mediate encephalitis, and aim to identify approaches in high risk patient populations, including those who are immunocompromised. We also aim to highlight emerging and re-emerging viral encephalitides and considerations in the pediatric population.

For this Research Topic we welcome submissions of articles related to the following themes:

1. Novel laboratory approaches to infectious and immune-mediated encephalitides;
2. Neuroimaging in infectious and immune-mediated encephalitides;
3. Differential diagnosis of acute infectious encephalitis;
4. Global emerging and re-emerging viral encephalitides;
5. Encephalitis in the immunocompromised population;
6. Acute encephalitis in the pediatric population.

Topic Editor Kenneth L Tyler has received research support from Taiga Biotechnologies Inc, Mapp Biopharmaceuticals and Antiplasmin Technologies. The other Topic Editors declare no competing interests with regard to the Research Topic subject.


Keywords: infectious encephalitis, autoimmune encephalitis, metagenomic next-generation sequencing, emerging infections, antiviral therapeutics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Neurologists’ knowledge of the expanding spectrum of infectious and immune-mediated encephalitides is a growing necessity in clinical practice. The impact of increasing globalization and expansion into previously undeveloped areas has led to the emergence of several viruses with a predilection for central nervous system (CNS) involvement. In parallel, the expansion of our knowledge of immune-mediated causes of encephalitis has led to growing complexity in defining the underlying causes of brain inflammation. With the expanded use of immunomodulators in various disease processes and immunotherapy in cancers, we are identifying a growing spectrum of previously unrecognized immune-mediated causes of CNS inflammation.

Despite recent advances in diagnostic and therapeutic modalities for infectious and autoimmune encephalitis, the management of patients with suspected or confirmed encephalitis poses a great challenge to physicians. In this Research Topic we aim to provide novel scientific data around laboratory testing for infectious and immune-mediate encephalitis, and aim to identify approaches in high risk patient populations, including those who are immunocompromised. We also aim to highlight emerging and re-emerging viral encephalitides and considerations in the pediatric population.

For this Research Topic we welcome submissions of articles related to the following themes:

1. Novel laboratory approaches to infectious and immune-mediated encephalitides;
2. Neuroimaging in infectious and immune-mediated encephalitides;
3. Differential diagnosis of acute infectious encephalitis;
4. Global emerging and re-emerging viral encephalitides;
5. Encephalitis in the immunocompromised population;
6. Acute encephalitis in the pediatric population.

Topic Editor Kenneth L Tyler has received research support from Taiga Biotechnologies Inc, Mapp Biopharmaceuticals and Antiplasmin Technologies. The other Topic Editors declare no competing interests with regard to the Research Topic subject.


Keywords: infectious encephalitis, autoimmune encephalitis, metagenomic next-generation sequencing, emerging infections, antiviral therapeutics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

20 July 2020 Abstract
13 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

20 July 2020 Abstract
13 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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