About this Research Topic
Neurological disorders comprise a variety of complex diseases affecting both the central and peripheral nervous systems and are increasingly recognized as major causes of death and disability worldwide. Nowadays, several different mutations in genes involved in the normal function of the brain, spinal cord, peripheral nerves or muscles have been associated with many neurological disorders either, acting alone or in combination with environmental factors. Over the past few years, the application of the different high-throughput approaches, also known as omics approaches (e.g. genomics, transcriptomics, proteomics, and metabolomics), has developed rapidly and enabled a much greater understanding in the etiology of many neurological disorders. Particularly, these new technologies have greatly advanced our ability to identify disease-related genes, biomarkers, and targets for potential therapeutic strategies. For this reason, omics techniques represent powerful tools for implementing and improving diagnostic procedures, and contribute to increasing the diagnostic yield for genetic neurological disorders.
Omics and multi-omics strategies are widely used in research for the investigation of the genetic and molecular basis of many neurological disorders. Additionally, their revolutionizing impact has contributed to significant medical advances for these types of diseases. Despite their successful application in research, omics techniques struggle to spread into clinical and diagnostic settings. Given their rapidly decreasing costs, the increasing standardization of protocols, and the amount of information obtainable at multiple biological levels in a reduced time, the integrated use of high-throughput omics technologies can represent a powerful addition to standard diagnostic procedures. This Research Topic is intended to showcase new methods and applications using omics or multi-omics approaches for improving the diagnosis of genetic neurological disorders, with the aim to highlight the extended potentialities and the challenges of these types of technologies.
This Research Topic is open to all studies using omics or multi-omics approaches and aims to improve the diagnosis in patients affected by genetic neurological disorders. We welcome submissions of Original Research, Methods and Reviews focusing on potential applications of omics technologies to increasing the diagnostic yield for neurological disorders. We believe that the integration of diverse types of data obtained at multiple biological levels through omics approaches could dramatically improve diagnostic practice, patient stratification, and disease management. This is an opportune moment to address how we can exploit all these potentialities to positively impact the clinical care of patients affected by genetic neurological disorders.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.