About this Research Topic
A similar approach, called ecoTTC, has been proposed for the establishment of environmental thresholds of concern. These can be derived for different species and modes of action. The underlying toxicity distributions can also be used to inform cross-species extrapolation. To date, the ecoTTC approach has not been used for regulatory purposes.
There are several important considerations that need to be investigated such as:
1) Applicability of established TTC values to different chemistries or are new TTC values warranted;
2) Evaluating the performance of assignment of chemicals to specific TTC categories based on different tools;
3) Addressing other routes of entry or exposure durations e.g. TTCs for inhalation, internal vs external TTCs.
4) Regulatory acceptance of TTC in different countries.
5) Definition of modes of action for aquatic organisms covering different chemistries and assignment of appropriate threshold values
6) Regulatory acceptance of the ecoTTC approach in environmental risk assessment
Please submit articles that describe the application of TTCs, ecoTTCs, or their refinement.
Topic editor, Dr. Yang has declared potential conflicts of interest with Molecular Networks GmbH. All other topic editors declare no competing interests with regards to the Research Topic subject.
Keywords: TTC, Threshold of toxicological concern, EcoTTC
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